Uniformed Services University

MCR4210, Molecular of Gonococcal Pathogenesis in Female Models of Disease
MCR4220 Helicobacter pylori-induced carcinogenesis
MCR4230, Molecular Genetics and regulation of Virulence Gene Expression in Shigella
MCR4240, Molecular Mechanisms of Enteric Bacterial Pathogenesis
MCR4250, Molecular Genetics and Pathogenic Mechanisms of Chlamydia

Course #: MCR4210, Molecular of Gonococcal Pathogenesis in Female Models of Disease
Course Type: C
Department: MCR
Duration: 4
Hours: 5
(Letter/Pass/Fail): P
 
Description: Participate in the ongoing research program within the laboratory. Current studies focus on the mechanisms used by Neisseria gonorrhoeae to evade host innate defenses of the female genital tract and the development of prophylactic agents against gonorrhea.
 
Sites: USUB

Course #: MCR4220 Helicobacter pylori-induced carcinogenesis
Course Type: C
Department: MCR
Duration: 4
Hours: 5
(Letter/Pass/Fail): P

Description: Research involves analysis of the interaction of the cancer-causing bacterium Helicobacter pylori with host cells. The goals of the work are to define bacterial genes required for colonization and disease and to elucidate and characterize host-signaling networks targeted by the bacterium that result in malignancy. Basic genetic, cellular, molecular and biochemical techniques will be covered.

Prior to registration, interested students should contact the course director to ensure availability of space.

Sites: USUB

Course #: MCR4230, Molecular Genetics and regulation of Virulence Gene Expression in Shigella
Course Type: C
Department: MCR
Duration: 4
Hours: 5
(Letter/Pass/Fail): P

Description: Participate in the ongoing research program within the laboratory. Current studies involve the study of secreted virulence products of Shigella, their role in pathogenesis, and how these proteins are transported out of the bacteria. Additional projects examine how gene loss contributed to teh evolution of Shigella from a commensal Escherichia coli.

Sites: USUB

Course #: MCR4240, Molecular Mechanisms of Enteric Bacterial Pathogenesis
Course Type: C
Department: MCR
Duration: 4
Hours: 5
(Letter/Pass/Fail): P

Description: Participate in the ongoing research program within the laboratory. Current studies concern the role of E. coli Shiga toxins in the pathogenesis of hemorrhagic colitis and the hemolytic uremic syndrome, analysis of the Rho-modifying cytotoxic necrotizing factor and its role in the pathogenesis of E. coli-mediated urinary tract infections, and evaluation of exosporium proteins of Bacillus anthracis as possible antigens to incorporate into the next generation anthrax vaccine.

Sites: USUB

Course #: MCR4250, Molecular Genetics and Pathogenic Mechanisms of Chlamydia
Course Type: C
Department: MCR
Duration: 4
Hours: 5
(Letter/Pass/Fail): P

Description: Participate in the ongoing research program within the laboratory. Current involve development of a system for genetic analysis of Chlamydia spp.; characterization of the pathway for peptidoglycan synthesis in Chlamydia; and identification of transport systems for uptake of nutrients essential for Chlamydia growth.

Sites: USUB