Recent Publications
Rank R.G., Bowlin A.K., Tormanen K.I., Wang Y., A.T. Maurelli. (2012) Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis. Infect Immun. 80(2):612-9.
Binet R., Fernandez R.E., Fisher D.J., A.T. Maurelli (2011) Identification and characterization of the Chlamydia trachomatis L2 S-adenosylmethionine transporter. MBio. 2(3):e00051-11.
Ramaswamy A.V., A.T. Maurelli. (2010) Chlamydia trachomatis serovar L2 can utilize exogenous lipoic acid through the action of the lipoic acid ligase LplA1. J Bacteriol. 192(23):6172-81.
Faherty C.S., D.S. Merrell, C. Semino-Mora, A. Dubois, A.V. Ramaswamy, A.T. Maurelli.
(2010) Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition. BMC Genomics. 11:272.
Binet R., A.K. Bowlin, A.T. Maurelli, R.G. Rank. (2010) Impact of azithromycin resistance mutations on the virulence and fitness of Chlamydia caviae in guinea pigs. Antimicrob Agents Chemother. 54(3):1094-101.
Binet R. and A.T. Maurelli.
2009. The chlamydial functional homolog of KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness. BMC Microbiol. 9:279.
Faherty C.S. and A.T. Maurelli. (2009) Spa15 of Shigella flexneri is secreted through the type III secretion system and prevents staurosporine-induced apoptosis. Infect. Immun. 77(12):5281-90.
Binet R. and A.T. Maurelli. 2009.
Transformation and isolation of
allelic exchange mutants of Chlamydia
psittaci using recombinant DNA
introduced by
electroporation. Proc
Natl Acad Sci U S A. 106(1):292-7.
Zurawski D.V., K.L. Mumy,
C.S. Faherty, B.A. McCormick, A.T. Maurelli. (2009) Shigella flexneri
type III secretion
system effectors OspB and OspF target the nucleus to downregulate the
host inflammatory
response via interactions with retinoblastoma protein.
Mol
Microbiol. 71(2):350-68.
Faherty C.S. and A.T. Maurelli. (2008)
Staying alive: bacterial inhibition
of apoptosis during infection. Trends
in Microbiology.16(4):173-80.
Review.
Zurawski D.V., K.L. Mumy, L. Badea, J.A. Prentice, E.L. Hartland, B.A.
McCormick BA, A.T.
Maurelli. (2008) NleE/OspZ family of effector proteins
is required for PMN transepithelial migration, a characteristic shared
by enteropathogenic Escherichia coli and Shigella flexneri
infections. Infect
Immun. 76(1):369-79.
Binet R. and A.T. Maurelli. (2007) Frequency of
Development and
Associated Physiological Cost of Azithromycin Resistance in Chlamydia
psittaci 6BC and C. trachomatis L2.
Antimicrob. Agents Chemother. 51(12):4267-75.
Prunier A.L., R. Schuch, R.E. Fernández, A.T. Maurelli.
2007.
Genetic Structure of the nadA and nadB Anti-virulence
Loci in Shigella spp. J Bacteriol. 189(17):6482-6.
Maurelli A.T. and AL Prunier AL. (2007) Mutations, Black Holes, and Antivirulence
Genes. Microbe.
August 2007.
Prunier AL, R. Schuch, R.E. Fernández, K.L. Mumy, H. Kohler, B.A.
McCormick, A.T. Maurelli. (2007) nadA and nadB
of Shigella flexneri 5a are antivirulence loci responsible for
the synthesis of quinolinate, a small molecule inhibitor of Shigella
pathogenicity. Microbiology.
153(Pt 7):2363-72.
Clark C.S. and A.T. Maurelli. (2007) Shigella flexneri
Inhibits
Staurosporine-Induced Apoptosis in Epithelial Cells. Infect
Immun. 75(5):2531-9.
Maurelli A.T.. (2007) Black holes, antivirulence genes, and
gene
inactivation in the evolution of bacterial pathogens. FEMS
Microbiol Lett. 267(1):1-8. Review.
McCoy A.J., N.E. Adams, A.O. Hudson, C. Gilvarg, T. Leustek, A.T.
Maurelli. (2006) L,L-diaminopimelate aminotransferase, a
trans-kingdom enzyme shared by Chlamydia and plants for
synthesis of diaminopimelate/lysine. Proc
Natl Acad Sci U S A. 103(47):17909-14.
Zurawski D.V., C. Mitsuhata, K.L. Mumy, B.A. McCormick, A.T.
Maurelli. (2006) OspF and OspC1 are Shigella flexneri type
III secretion system effectors that are required for postinvasion
aspects of virulence. Infect
Immun. 74(10):5964-76.
McCoy A.J. and A.T. Maurelli. (2006) Building the
invisible
wall: updating the chlamydial peptidoglycan anomaly. Trends
Microbiol. 14(2):70-7.
Binet R. and A.T.
Maurelli. (2005) Fitness cost due to mutations in the 16S rRNA
associated with spectinomycin resistance in Chlamydia psittaci
6BC. Antimicrob.
Agents Chemother. 49(11):4455-64.
Binet R. and A.T. Maurelli. (2005) Frequency of
spontaneous mutations that confer antibiotic resistance in Chlamydia
spp.. Antimicrob.
Agents Chemother. 49 (7): 2865-2873.
McCoy A.J., and A.T. Maurelli. (2005)
Characterization of Chlamydia MurC-Ddl, a fusion protein
exhibiting D-alanyl-D-alanine ligase activity involved in peptidoglycan
synthesis and D-cycloserine sensitivity. Mol. Micro.
57 (1): 41-52.
Honma Y., R.E. Fernández, A.T. Maurelli. (2004) A
DNA adenine methylase mutant of Shigella flexneri shows no
significant attenuation of virulence. Microbiology.
150(Pt 4):1073-8.
Verma A., and A.T.
Maurelli. (2003) Identification of two eukaryote-like
serine/threonine kinases encoded by Chlamydia trachomatis
serovar L2 and characterization of interacting partners of Pkn1. Infect
Immun. 71(10):5772-84.
McCoy A.J., R.C. Sandlin, A.T.
Maurelli. 2003. In vitro and in vivo functional
activity of Chlamydia MurA, a UDP-N-acetylglucosamine
enolpyruvyl transferase involved in peptidoglycan synthesis and
fosfomycin resistance. J.
Bacteriol. 185(4):1218-28.
Kohler H, S.P. Rodrigues, A.T. Maurelli, B.A. McCormick. (2002) Inhibition of Salmonella typhimurium
enteropathogenicity by piperidine, a metabolite of the polyamine
cadaverine. J.
Infect Dis. 186(8):1122-30.
Kane CD, R. Schuch, W.A. Day, A.T. Maurelli. (2002)
MxiE
regulates intracellular expression of factors secreted by the Shigella
flexneri 2a type III secretion system. J.
Bacteriol. 184(16):4409-19.
Schuch, R and A.T.
Maurelli. (2001) MxiM and MxiJ, base elements of the
Mxi-Spa type III secretion system of Shigella, interact with
and stabilize the MxiD secretin in the cell envelope. J.
Bacteriol. 183(24):6991-8.
Day W.A. Jr, R.E.
Fernández, A.T. Maurelli. (2001) Pathoadaptive
Mutations That Enhance Virulence: Genetic Organization of the cadA
Regions of Shigella spp. Infect.
Immun. 69:7471-80
Fernandez, I.M., M. Silva, R. Schuch, W.A. Walker, A.M. Siber, A.T.
Maurelli, B.A. McCormick. (2001) Cadaverine prevents the
escape of Shigella flexneri from the phagolysosome: a
connection between bacterial dissemination and neutrophil
transepithelial signaling. J.
Infect. Dis. 184:743-53.
Schuch, R., and A.T.
Maurelli. (2001) Spa33, a cell surface-associated
subunit of the Mxi-Spa type III secretory pathway of Shigella
flexneri, regulates Ipa protein traffic. Infect.
Immun. 69:2180-9.
Day W.A. Jr. and A.T.
Maurelli. (2001) Shigella flexneri LuxS
quorum-sensing system modulates virB expression but is not
essential for virulence. Infect.
Immun. 69:15-23.
Schuch R., R.C. Sandlin,
and A. T. Maurelli. (1999) A system for identifying
post-invasion functions of invasion genes: requirements for the Mxi-Spa
type III secretion pathway of Shigella flexneri in
intercellular dissemination. Mol.
Microbiol. 34:675-689.
McCormick B.A., M. I.
Fernandez, A.M. Siber, and A. T. Maurelli. (1999)
Inhibition of Shigella flexneri-induced transepithelial
migration of polymorphonuclear leukocytes by cadaverine. Cell.
Microbiol. 1:143-155.
Schuch R., and A. T.
Maurelli. (1999) The Mxi-Spa type III secretory pathway
of Shigella flexneri requires an outer membrane lipoprotein,
MxiM, for invasin translocation. Infect.
Immun. 67:1982-1991.
Sandlin R.C., and A.
T. Maurelli. (1999) Establishment of unipolar
localization of IcsA in Shigella flexneri 2a is not dependent
on virulence plasmid determinants. Infect.
Immun. 67:350- 356.
Maurelli A.T.,
P.R. Routh, R.C. Dilman, M. D. Ficken, D. M. Weinstock, G. W. Almond,
and P. E. Orndorff. (1998) Shigella infection as observed in the
experimentally inoculated domestic pig, Sus scrofa domestica. Microbial
Pathogen. 25:189-196.
McCormick B.A., A.M.
Siber, and A.T. Maurelli. (1998) Requirement of the Shigella
flexneri virulence plasmid in the ability to induce trafficking of
neutrophils across polarized monolayers of the intestinal
epithelium. Infec.
Immunity. 66:4237-4243.
Maurelli A.T.,
R.E. Fernández, C.A. Bloch, C.K. Rode, and A. Fasano. (1998) "Black
holes" and bacterial pathogenicity: A large genomic deletion that
enhances the virulence of Shigella spp. and enteroinvasive Escherichia
coli. Proc.
Natl. Acad. Sci. USA. 95:3943-3948.
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