This page last updated  02/27/07

Haigney,
Mark, MD, FAHA

Associate Prof. of Medicine
Director, Division of Cardiology

 

Cardiology

 Mechanisms of sudden death and progression of heart failure, with emphasis on: 1. modulation of Na/Ca exchange in healthy and heart failure swine; 2. role of unstable repolarization in arrhythmogenesis in man and swine; 3. role of aldosterone in the progression of systolic heart failure.


RECENT PUBLICATIONS :

1. Wei SK, Ruknudin A, Hanlon SU, McCurley JM, Schulze D, Haigney MCP. PKA hyperphosphorylation increases basal current but decreases β-adrenergic responsiveness of the sarcolemmal Na+/Ca2+ exchanger in failing pig myocytes. Circulation Research, 2003; 92: 897-903.

2. Domanski M, Norman J, Pitt B, Haigney M, Hanlon S, Peyster E: Diuretic Use, Progressive Heart Failure, and Death In Patients in Studies of Left Ventricular Dysfunction (SOLVD). Journal of the American College of Cardiology, 2003;42:705-708.

3. McCurley JM, Hanlon SU, Wei SK, Wedam EF, Michalski M, Haigney MC: Furosemide Accelerates the Progression of Left Ventricular Dysfunction in Experimental Heart Failure. J American College of Cardiology, 2004;44(6):1301-7.

4. Nasir J, Durning S, Barold HS, Ferguson M, Haigney MC. Exercise-induced syncope and QT prolongation after “ephedra-free” xenadrine exposure. Mayo Clinic Proceedings, 2004 Aug;79(8):1059-62.

5. Haigney MC, Zareba W, Gentlesk P, Goldstein RE, Illovsky M, McNitt S, Moss A. QT Interval Variability and Spontaneous Ventricular Tachycardia or Fibrillation in MADIT II Patients. Journal of the American College of Cardiology, 2004; 44(7): 1481-1487.

6. Haigney MC, Alam S, Tebo S, Marhefka G, Elkashef A, Kahn R, Chang N, Vocci F, Cantilena L. Intravenous cocaine and QT variablity. Journal of Cardiovascular Electrophysiology.. 2006 Jun;17(6):610-6. Published online first doi:10.1111/j.1540-8167.2006.00421.

7. Domanski M, Tian X, Haigney M, Pitt B. Diuretic use, progressive heart failure, and death in patients in the DIG study. J Card Fail. 2006 Jun;12(5):327-32.

8. Haigney MC. Percutaneous Intrapericardial Cardiac Echo: So now that you’re here, take a picture… Heart Rhythm. 2006 Nov;3(11):1283-4.

9. Wei SK, Mccurley JM, Hanlon SU, Haigney MC. Gender Differences in Na/Ca Exchanger Current and β-adrenergic Responsiveness in Heart Failure. New York Academy of Sciences. In Press.

10. Ruknudin AM, Wei SK, Haigney MC, Lederer WJ, Schulze DH. Phosphorylation and other conundrums of Na/Ca exchanger, NCX1. New York Academy of Sciences. In Press.

11. Wei SK, Ruknudin AM, Shou M, McCurley J, Hanlon SU, Elgin E, Schulze D, Haigney MC. Muscarinic modulation of the sodium-calcium exchanger in heart failure. Circulation. In Press.


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