Uniformed Services University of the Health Sciences
Department of Pharmacology
4301 Jones Bridge Road
Bethesda, Maryland 20814-4799
Phone: (301) 295-3223
FAX: (301) 295-3220
Associate Professor, Department of Pharmacology
Epileptogenesis is the process by which a normal brain becomes chronically prone to seizures. Many brain insults, including stroke, trauma, and neurodegenerative disease, can induce epileptogenesis but no therapies exist to prevent it. Reorganization of neuronal circuits and alterations in individual synapses are associated with epileptogenesis. However, the functional consequences and relative importance of these changes to epileptogenesis remain unknown. Our research goals are to elucidate the extent, the functional consequences and the mechanisms underlying these synaptic alterations and to test potential anti-epileptogenic therapies.
To attain these goals, we use electrophysiology (whole-cell, extracellular, multi-electrode array, and in vivo video EEG) in combination with pharmacological manipulations, 2-photon microscopy as well as immunohistochemistry and histology. Experiments are performed on hippocampal tissue taken from in vivo and in vitro rodent models of epileptogenesis and temporal lobe epilepsy including traumatic brain injury, status epilepticus models, and organotypic hippocampal slice cultures.
Current studies focus on the use of NMDA receptor antagonists to prevent post-traumatic epileptogenesis.