Uniformed Services University of the Health Sciences
Department of Pathology
4301 Jones Bridge Road, C1094
Bethesda, Maryland 20814-4799
Phone: (301) 295-3450
fax: (301) 295-1640
General: Regulation of gene expression related to cell growth control; protein-DNA and protein-protein interactions involved in cell growth control; tumor suppressor genes — identification and analysis; anti-cancer effects of interferons.
Specific: Mechanism of tumor suppression exerted by lysyl oxidase in mammalian cells; mechanism by which ras oncogene over expression down regulates lysyl oxidase transcription; role of Ras in the mammalian cell nucleus; mechanism of action of interferon and retinoic acid in re-activation of lysyl oxidase gene expression; role of de-methylation in lysyl oxidase transcription down regulation.
Contente, S., Yeh, T.J., Friedman, R.M. (2011) H-Ras localizes to cell nuclei and varies with the cell cycle. Genes & Cancer 2(2) 166-172. DOI: 10.1177/1947601911405042.
Contente , S., Yeh, T.J., Friedman, R.M. (2009) Tumor suppressive effect of lysyl oxidase proenzyme. Biochim Biophys Acta 1793 1272-8
Contente, S., Attard, F A., Friedman, R.M. (2006) Identification of proteins immunologically related to interferon regulatory factor-1 that bind with interferon regulatory factor element. J Infect Dis 194 Suppl 1 S27-S32.
Yeh, T.A., Contente, S., Friedman, R.M. (2005) Transformation of revertant murine cells by 5-azacytidine results in rapid inhibition of lysyl oxidase expression. Acta Microbiol et Immunol Hung 52 433-442.
Attard, F A., Contente, S., Yeh, T.A., Buchhagen, D.L., Friedman, R.M. (2005) Mechanisms of deregulation of interferon regulatory factor-1 in ras-transformed fibroblasts. J Interferon Cytokine Res 25 418-423.
Contente, S., Attard, F A., Yeh, T.A., Buchhagen, D.L, Friedman, R.M. (2003) Deregulated expression of interferon regulatory factor-1 in oncogene-transformed mouse fibroblasts. J Interferon Cytokine Res 23 639-647.
Friedman, R. M., Yeh, A., Gutman, P., Contente, S., and Kenyon, K. (1997) Reversion by deletion of transforming oncogene following interferon- and retinoic acid treatment. J Interferon Cytokine Res 17 647-651.
Mello, M.L.S., Contente, S., Vidal, B.C., Planding, W., Schenck, U. (1995) Modulation of ras transformation affecting chromatin supraorganization as assessed by image analysis. Exp Cell Res 220 374-382.
Kenyon, K., Modi, W.S., Contente, S., Friedman, R.M. (1993) A Novel Human cDNA with a Predicted Protein Similar to Lysyl Oxidase Maps to Chromosome 15q24-q25. J Biol Chem 268 18435-18437.
Kenyon, K., Contente, S., Trackman, P.C., Tang, J., Kagan, H.M., Friedman, R.M. (1991) Lysyl oxidase and rrg messenger RNA. Science 253 802.