Department of Pathology: Faculty
Uniformed Services University of the Health Sciences
Department of Pathology
4301 Jones Bridge Road, C1094
Bethesda, Maryland 20814-4799
Phone: (301) 295-3450
fax: (301) 295-1640
Robert M. Friedman, M.D.
- A.B. Cornell University, 1954
- M.D. New York University, 1958
Current Research Interests
Interferons are regulators of cell growth and differentiation. Our studies indicate that interferons induce reversion of H-ras-transformed cells by increasing the expression of the gene for the extracellular enzyme, lysyl oxidase. We are currently investigating the regulation of the expression of this gene.
Friedman Robert M., Yeh Annie, Gutman Pablo, Contente Sara, and Kenyon Kaylene: Reversion by Deletion of transforming oncogene following Interferon-beta and Retinoic Acid Treatment. Journal of Interferon and Cytokine Research 17:647-651, 1997.
Friedman, Robert M.: I Listened to my Grass Roots, But Heard Only Murmurs of Discontent. Cytokine and Growth Factor Reviews, Vol. 8, 2:101, 1997.
Friedman, Robert M.: Foreword. Journal of Interferon and Cytokine Research 17:Supplement 1:S1 (1997).
Contente Sara, Kenyon Kaylene, Sriraman Priya, Subramanyan Savitri, and Friedman Robert M.: Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. Molecular and Cellular Biochemistry 194:79-91, 1999.
Naniche Denise, Yeh Annie, Eto Danelle, Manchester Marianne, Friedman Robert M., and Oldstone Michael B.A: Evasion of Host Defenses by Measles Virus: Wild-Type Measles Virus Infection Interferes with Induction of Alpha/Beta Interferon Production. Journal of Virology 74:7478-7484, 2000.
Contente Sara, Attard Frank A., Yeh Tze-Jou Annie, Buchhagen Dorothy L., & Friedman Robert M.: Deregulated Expression of Interferon Regulatory Factor- 1 in Oncogene-Transformed Mouse Fibroblasts. Journal of Interferon & Cytokine Research 23: 639-647, 2003.
Attard Frank A., Contente Sara, Yeh Tze-Jou Annie, Buchhagen Dorothy L., & Friedman Robert M.: Mechanisms of Deregulation of IFN Regulatory Factor-1 in ras-Transformed Fibroblasts. Journal of Interferon & Cytokine Research 25: 418-423, 2005.
Yeh Annie Tze-Jou, Contente Sara, & Friedman Robert M.: Transformation of Revertant Murine Cells by 5-Azacytidine Results in Rapid Inhibition of Lysyl Oxidase Expression. Acta Microbiologica et Immunologica Hungarica 52:433-442 (2005).
Contente Sara, Attard Frank A., & Friedman Robert M.: Identification of Proteins Immunologically Related to Interferon Regulatory Factor 1 That Bind with Interferon Regulatory Factor Element. Journal of Infectious Dis. 194 (Suppl. 1):S27-32 (2006)