Uniformed Services University of the Health Sciences
Medical and Clinical Psychology
4301 Jones Bridge Road
Bethesda, Maryland 20814-4799
Phone: (301) 295-3273
FAX: (301) 295-3034
Professor and Chair, Medical & Clinical Psychology
Education: B.S. (1971) in Psychology, City College of New York; Ph.D. (1975) in Psychology, University of Texas at Austin
Research Topics: The focus of Dr. Krantz's research is on the effects of psychosocial stress on health, and on the role of psychological factors in cardiovascular disorders-- a field on the interface of health psychology and cardiology. He has extensively studied the effects of acute stress as a precipitating factor for coronary heart disease events such as myocardial ischemia and malignant arrhythmias. He is Principal Investigator of the BETRHEART Study, which investigates the role of stress and behavior in the progression of heart failure. He also collaborates with investigators at other institutions to examine psychosocial influences on coronary heart disease in women. His research involves both clinical studies and using epidemiologic databases. He also is Principal Investigator of the Center for Deployment Psychology, a major national post-graduate educational program of the Department of Defense to train mental health providers to treat deployment-related behavioral health issues in military service members and their families.
Methods and Approach: clinic-based and laboratory-based human experiments with cardiovascular patients and healthy volunteers; ambulatory monitoring
Current Grant Support: NHLBI, NIH
Medical Student Teaching: lectures on Medical Psychology and Cardiovascular Diseases
Graduate Student Teaching: graduate courses on Research Methods, Personality, Behavioral Factors in Chronic Disease.
Mentoring: Dr. Krantz has supervised 17 doctoral dissertations in Medical Psychology and has trained 11 post-doctoral fellows. He currently is training four Ph.D. students in his laboratory.
Kop WJ, PhD, Weissman NJ Zhu J, Bonsall RW, Doyle M, Stretch MR, Glaes SB, Krantz DS, Gottdiener JS, Tracy RP. Effects of Acute Mental Stress and Exercise on Inflammatory Markers in Patients with Coronary Artery Disease and Healthy Controls. American Journal of Cardiology, 2008, 15;101(6):767-73.
Francis JL, Weinstein AA, Krantz DS, Haigney MC, Stein PK, Stone PH, Gottdiener JS, Kop WJ. Association between Depression and Anxiety with Heart Rate Variability in Patients with Implantable Cardioverter Defibrillators. Psychosomatic Medicine, 2009, 71:821-827.
Krantz DS, Whittaker KW, Francis JL, Rutledge T, Johnson D, Barrow G, McClure S; Sheps DS, York K, Cornell C, Bittner V, Vaccarino V, Eteiba W, Parashar S, MD, Vido DA, Merz CNB. Psychotropic Medication Use and Risk of Adverse Cardiovascular Events in Women with Suspected Coronary Artery Disease: Outcomes from the Women's Ischemia Syndrome Evaluation (WISE) Study. Heart, 2009,;95(23):1901-6.
Rutledge T. Linke SE., Krantz DS, Johnson D., Bittner V., Eastwood J., Eteiba W., Pepine CJ., Vaccarino V., Francis J., Vido DA., Bairey Merz, CN. Comorbid depression and anxiety symptoms as predictors of cardiovascular events: Results from the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study. Psychosomatic Medicine, 2009,71(9):958-64.
Krantz DS, Whittaker KS, Sheps DS. Psychosocial risk factors for Coronary Artery Disease: Pathophysiologic Mechanisms. In R. Allan (Ed.), Heart and Mind: Evolution of Cardiac Psychology. Washington DC, APA Press, 2011.
Rutledge T, Linke SE, Johnson BD, Bittner V, Krantz DS, Whittaker KS, Eastwood JA, Eteiba W, Cornell CE, Pepine CJ, Vido DA, Olson MB, Shaw LJ, Vaccarino V, Bairey Merz CNB. Self-rated versus Objective Health Indicators as Predictors of Cardiovascular-Related Death and Events: the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study. Psychosomatic Medicine 2010;72(6):549-55.
Ketterer M, Bekkouche N, Goldberg D, McMahon RP, Krantz DS. Symptoms of anxiety & depression are correlates of angina pectoris by recent history & on an ischemia positive treadmill test in patients with documented coronary artery disease," Cardiovascular Psychiatry and Neurology, vol. 2011, Article ID 134040, 7 pages, 2011. doi:10.1155/2011/134040
Rutledge T. Linke SE., Johnson BD., Bittner V., Krantz DS, Cornell CE, Vaccarino V., Pepine CJ., Handberg EH, Eteiba W., Shaw LJ, Parashar S, Eastwood J., Vido DA, Bairey Merz, CN. Independent relationships between cardiovascular disease (CVD) risk factors and depressive symptoms as predictors of CVD events. Journal of Womens Health, 2012 (2):133-9
Whittaker KS, Krantz DS, Rutledge T, Johnson BD, Bekkouche N, Bittner V, Eastwood JA, Eteiba W, Cornell CE, Pepine CJ, Vido DA, Handberg W, Merz CNB. Combining psychosocial data to improve cardiovascular disease risk marker estimation and event prediction in the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study. Psychosomatic Medicine, 2012 74(3):263-70.
Rutledge T, Kenkre TS, Bittner V, Krantz DS, Thompson DV, Linke SE, Eastwood JA, Eteiba W, Cornell CE, Vaccarino V, Pepine CJ, Johnson BD, Merz CNB. International Journal of Cardiology (in press). Anxiety Associations with Cardiac Symptoms, Angiographic Disease Severity, & Healthcare Utilization: The NHLBI-Sponsored Women's Ischemia Syndrome Evaluation. International Journal of Cardiology, Feb 11. doi:pii: S0167-5273(13)00076-4. 10.1016/j.ijcard.2013.01.036. [Epub ahead of print]
Bekkouche NS, Wawrzyniak AJ, Whittaker KS, Ketterer MW, Krantz DS. Assessment and comparison of variables predicting exercise-induced angina: The role of angina history, depression, and anxiety. Psychosomatic Medicine, 2013 May;75(4):413-21.
Suls J, Krantz DS, Williams GC. Three strategies for bridging different levels of analysis and embracing the biopsychosocial model. Health Psychology, 2013 May;32(5):597-601.
Wawrzyniak, AJ, Bekkouche, NS, Krantz, DS. (2012). Acute behavioural and psychological triggers of acute myocardial infarction. In Waldstein S, Katzel L& Kop WJ. Cardiovascular Behavioral Medicine. (in press).
Eastwood JA, Johnson BD, Rutledge T, Bittner V, Whittaker KS, Krantz DS, Cornell CD, Eteiba W, Handberg E, Vido D, Bairey Merz CNB. Anginal Symptoms, Angiographic Coronary Artery Disease, and Adverse Outcomes in Black and White Women: The NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study.
Handberg EM, Eastwood JA, Eteiba W, Johnson BD, Krantz DS, Thompson DV, Vaccarino V, Bittner V, Sopko G, Pepine CJ, Merz NB, Rutledge TR. Clinical implications of the Women's Ischemia Syndrome Evaluation: inter-relationships between symptoms, psychosocial factors and cardiovascular outcomes. Womens Health (Lond Engl). 2013 Sep;9(5):479-90.
Dr. Krantz is a fellow of the American Psychological Association, Academy of Behavioral Medicine Research, and the Society of Behavioral Medicine. He also is a member of the American Psychosomatic Society. He has served as president of the Health Psychology Division of the American Psychological Association, president of the Academy of Behavioral Medicine Research, Editor-in-Chief of Health Psychology, as a Council Member of the American Psychosomatic Society, and as a member of many scientific review panels.
American Psychological Association's Early Career Scientific Award (1982), American Psychological Association's Award for Outstanding Contributions to Health Psychology (1981, 2000).