Neuroregeneration Program

The Neuroregeneration Program will develop approaches to address damage and dysfunction that cannot be prevented. Neuroregenerative approaches will include stimulation of the repair capacity of endogenous neural stem and progenitor cell populations, tissue modifications to reduce environmental factors that inhibit repair, and transplantation paradigms using exogenous stem cell populations.

Neuroregeneration Program Primary Goals:

The Neuroregeneration Program will address TBI repair using three overall approaches:

  • Stimulation of endogenous neural stem-progenitor (NS-P) cell regeneration
  • Transplantation of exogenous stem cell populations to promote regeneration
  • Modification of features of the lesion environment that inhibit repair

Critical Issues for the Neuroregeneration Program:

  • New neurons are generated throughout adulthood from several populations of progenitor cells, but these cells normally only make certain types of neurons.
  • Environmental signals and immune responses may limit the numbers and types of neurons generated in the adult brain.
  • The most significant benefit to cell transplantation in the nervous system has not been replacement of lost neurons and glia but rather modulation of the lesion environment and/or the immune response to promote regenerative responses from the immature endogenous cells.

Neuroregeneration Program Projects and Pilots

Click here to download project and pilots abstracts

Principal Investigator
Denes Agoston
Improving Neuroregeneration after exposures to multiple mild blasts

Regina Armstrong
Neural Stem-Progenitor Cell Repair Potential at Distinct Sites of TBI Pathology

Leonardo Belluscio
Using the Mouse Olfactory System as a Model for Studying TBI

Rachel Cox
Characterizing mitochondrial Ca+2 homeostasis and the effects of oxidative damage

Martin Doughty
HDAC inhibitor effects on adult neurogenesis post-TBI

Yang Du Genetic
Identification of neural stem cell self-renewal regulators

Ying-Hong Feng
Generation of iPS cells without vector

Joseph Frank
Tracking labeled stem cells in TBI model by cellular MRI

Sharon Juliano
Using Neural stem/progenitor cells to repair simple neural circuits after TBI

Brian Schaefer
Modulation of NF-kB-dependent immune responses for post-TBI neuroregeneration

Aviva Symes
Altering the ECM after TBI to enhance regeneration and plasticity

Denes Agoston
Exploring strategies to improve outcome after repeated mild blast TBI

Regina Armstrong
Enhancing neural stem cell activation to improve white matter recovery from mild TBI

Martin Doughty
Targeting the epigenome to treat mTBI

Aviva Symes
Pre-clinical development of angiotensin receptor blockers for treatment of TBI

Martin Doughty
Epigenetic optimization of neuronal cell replacement strategies using induced pluripotent stem cells (iPSCs)
Pilots and Fellowships
Joseph Frank
Macrophage subsets in TBI

Brian Schaefer
Assessment of neurotrophin involvement and anti-inflammatory therapy in TBI

Aviva Symes
Angiotensin receptor blocker as potential therapeutics for TBI

Xianoyuan Chen
Mesenchymal Stem Cell-Based TBI Treatment and Therapy Effect Monitoring

Amanda Mierzwa
Evolution of Hedgehog Signaling and Oxidative Stress Following Mild TBI

Lisa Turtzo
Modulation of Inflammation after TBI

Sonia Villapol
Angiotensin II Receptor Blockers as Potential Therapeutics for TBI

Jae-Hyuk John Yi
Altering the ECM after TBI to Enhance Regeneration and Plasticity