Neuroplasticity Program

The Neuroplasticity Program will focus on recovery approaches that modify synapses and circuits to enhance functional capacity. Neuroplasticity strategies will attempt to maximize function from existing cells as a critical component of promoting recovery from traumatic brain injury (TBI). Neuroplasticity studies will assist the development of neuroregenerative strategies since newly generated cells must establish the appropriate neuronal-glial interactions and/or integrate into the appropriate circuitry to contribute to the recovery of function.

Neuroplasticity Program Primary Goals:

  • Understand the biological consequences of traumatic brain injury (TBI) that impair central nervous system structural and functional repair.
  • Develop neurobiological approaches to aid recovery of neurological and cognitive function.
  • Characterize neural maps within the cerebral cortex and limbic system that are associated with the changes resulting from TBI and possibly altered with treatment.

Critical Issues for the Neuroplasticity Program:

  • Underlying predictors of impaired cognitive and sensory motor learning skills accompany many forms of TBI.
  • Environmental stress affects TBI symptomatology.
  • Diffuse axonal injury is associated with specific forms of TBI and can disrupt function throughout diverse neural circuits.
  • Glial and immune response in TBI can alter neuronal function.

Neuroplasticity Program Research Projects and Pilots

Click here to download project and pilots abstracts

Principal Investigator
Christopher Baker
Neuroplasticity in human sensory cortex

Suzanne Bausch
Functional Maps of Neuronal and Glial Activity Following TBI, Stress and TBI

Leonardo Cohen
Motor learning after TBI

Zygmunt Galdzicki
Epigenetic factors and cortical map plasticity in the model of TBI

Jordan Grafman
Executive Function & Social Cognitive Adaptive Neuroplasticity

Luke Johnson
Differential Dysregulation of Subcortical Synaptic Plasticity after TBI

Sharon Juliano
Does TBI alter extrinsic and intrinsic connectivity in sensory cortex?

Michael Schell
Development of an organotypic brain slice model for shear injury

Eric Wassermann
The role of reward in human neuroplasticity

Xin Xiang
Retrograde injury signaling and cytoskeletal alterations in barrel cortex after TBI

Suzanne Bausch
NR2B-selective antagonist to ameliorate posttraumatic epileptogenesis and its associated comorbidities

Leonardo Cohen
Improving rehabilitation of Decision Making deficits after TBI

Sharon Juliano
Does training influence cortical remodeling after TBI?

Zygmunt Galdzicki
Microglia Mediated Mechanisms of Vasculature and Neuronal Network Dysfunction Following Repetitive TBI

Andrew Holmes
Optogenetic control and recovery of PTSD relevant behavioral abnormalities caused by TBI

Carlos Pierpaoli
Mapping brain structural changes following rehabilitation treatments for mild TBI in military subjects with advanced diffusion MRI
Pilots and Fellowships
Eric Wassermann
Monitoring cognitive function in the prefrontal cortex functional near-infrared spectroscopy (fNIRS)

Manoj Jaiswal
Balance between Inhibition and Excitation and the Vascular Trauma in Sensory Barrel Cortex after TBI

Aysha Keisler
Contributions of Cost and Reward Response to Fatigue

Jennifer McGuire
Propagated Deep Brain Neuronal Plasticity after Prefrontal Cortical Injury