Neuroplasticity Program

The Neuroplasticity Program will focus on recovery approaches that modify synapses and circuits to enhance functional capacity. Neuroplasticity strategies will attempt to maximize function from existing cells as a critical component of promoting recovery from traumatic brain injury (TBI). Neuroplasticity studies will assist the development of neuroregenerative strategies since newly generated cells must establish the appropriate neuronal-glial interactions and/or integrate into the appropriate circuitry to contribute to the recovery of function.

Neuroplasticity Program Primary Goals:

  • Understand the biological consequences of traumatic brain injury (TBI) that impair central nervous system structural and functional repair.
  • Develop neurobiological approaches to aid recovery of neurological and cognitive function.
  • Characterize neural maps within the cerebral cortex and limbic system that are associated with the changes resulting from TBI and possibly altered with treatment.

Critical Issues for the Neuroplasticity Program:

  • Underlying predictors of impaired cognitive and sensory motor learning skills accompany many forms of TBI.
  • Environmental stress affects TBI symptomatology.
  • Diffuse axonal injury is associated with specific forms of TBI and can disrupt function throughout diverse neural circuits.
  • Glial and immune response in TBI can alter neuronal function.

Neuroplasticity Program Research Projects and Pilots

To view all CNRM funded research projects:

  • Visit the Federal RePORTER website
  • Next to Agency, click "Select"
  • From the drop down, click "Clear"
  • Select the + by "Defense" and click the box for "Center for Neuroscience and Regenerative Medicine"
  • Click "Select" and then "Submit Query"