Symposium agenda

Agenda for International Biodosimetry Research Symposium

Sponsored by:

Armed Forces Radiobiology Research Institute at the Uniformed Services University of the Health Sciences in Bethesda, Maryland

Venue

AFRRI Conference Room
8901 Wisconsin Avenue, Bethesda, MD

Monday, April 18, 2011

TIME	EVENT
7:30 a.m.	Registration
8:30 a.m.	Administrative remarks CPT N.H. Latif, MS, H(ASCP) Armed Forces Radiobiology Research Institute in Bethesda, Maryland
8:35 a.m.	Welcome COL M.A. Melanson, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland
8:40 a.m.	Introduction—AFRRI's Biodosimetry Research Program W.F. Blakely, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland

SESSION I—Validation of Biodosimetry Applications Using Animal Radiation Models—Part I
Co-chairs: G.L. King and A. Romanyukha

TIME	EVENT
9:00 a.m.	Dosimetry for animal radiation models V. Nagy, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland
9:30 a.m.	Hematological changes as prognostic indicators of survival in irradiated minipigs M. Moroni, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland
10:00 a.m.	Poster Break
10:20 a.m.	In vivo tooth EPR biodosimetry in human and NHP models B. Williams, PhD Dartmouth University in Hanover, New Hampshire
10:50 a.m.	The combined measurement of radiation-induced changes in plasma DNA and white blood cell counts as a novel biodosimeter P. Okunieff, MD Department of Radiation Oncology, University of Florida College of Medicine in Gainesville, Florida
11:20 a.m.	Metabolomics for discovery of urinary radiation biomarkers C. Johnson, PhD Laboratory of Metabolism, CCR/NCI/NIH in Bethesda, Maryland
11:50 a.m.	Lunch Break

SESSION II—Validation of Biodosimetry Applications Using Animal Radiation Models—Part II
Co-chairs: N.I. Ossetrova and S.G. Swarts

TIME	EVENT
1:30 p.m.	Assessment of total- and partial-body irradiation in a baboon model: A comparative multiparametric study of chromosomal aberrations and hematological, biochemical and genomic parameters/preliminary results F. Hérodin, PhD Centre de Recherches du Service de Sant des Armes in France
2:00 p.m.	ARS severity response scoring system for the Rhesus macaque G.L. King, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland
2:30 p.m.	Early-response biological dosimetry using hematological profile—NHP dose response W.F. Blakely, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland
3:00 p.m.	Poster Break
3:20 p.m.	Protein biomarkers for enhancement of radiation dose and injury assessment in nonhuman primate radiation model N.I. Ossetrova, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland

PLENARY LECTURE
Chair: W.F. Blakely

TIME	EVENT
3:50 p.m.	A nonhuman primate research platform: Development of biomarkers for hematopoietic, GI and lung sequelae T.J. MacVittie, PhD University of Maryland in Baltimore
4:50 p.m.	Adjourn

Tuesday, April 19, 2011

TIME	EVENT
7:30 a.m.	Registration
8:00 a.m.	Welcome and administrative remarks

SESSION III—Human Biodosimetry—Use of Clinical Laboratory Data and ARS Signs and Symptoms
Co-chairs: A.L. Wiley Jr. and R.E. Goans

TIME	EVENT
8:30 a.m.	Predicting hematological ARS severity scores based on peripheral blood cell counts taken within the first 3 days after radiation exposure M. Abend, MD, PhD Bundeswehr Institute of Radiobiology in Munich, Germany
9:00 a.m.	Multiple parameter biodosimetry lessons from clinical cases of human overexposures R.E. Goans, MD, PhD MJW Corp., Amherst NY and Radiation Emergency Assistance Center/Training Site in Oak Ridge, Tennessee

SESSION IV—Cytogenetic Biodosimetry—Part I
Co-chairs: A.C. Miller and M. Yoshida

TIME	EVENT
9:30 a.m.	Gamma-H2AX assay as an ionizing radiation biodosimeter C. Redon, PhD National Institutes of Health in Bethesda, Maryland
10:00 a.m.	Poster Break
10:20 a.m.	Optimization of calyculin A-induced PCC assay T. Miura, PhD Hirosaki University in Japan
10:50 a.m.	Development of a novel chromosomal bioassay to discriminate military-relevant toxic exposures A.C. Miller, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland

SESSION V—Cytogenetic Biodosimetry—Part II
Co-chairs: A. Ramakumar and P.G.S. Prasanna

TIME	EVENT
11:20 a.m.	Towards a North American network for biological dosimetry R. Wilkins, PhD Health Canada, Consumer and Clinical Radiation Protection Bureau in Ottawa, Canada
11:50 a.m.	Lunch Break
1:30 p.m.	Use of the internet to facilitate network scoring of chromosomal aberrations G. Livingston, PhD Radiation Emergency Assistance Center/Training Site, ORISE in Oak Ridge, Tennessee
2:00 p.m.	Automated cytogenetics for biodosimetry applications A. Ramakumar, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland
2:30 p.m.	The RABiT: A Rapid Automated Biodosimetry Tool for radiological triage G. Garty PhD Columbia University in New York City, New York
3:00 p.m.	Poster Break

SESSION VI—Perspectives in Translational Biodosimetry
Co-chairs: COL M.A. Melanson and C.R. Lissner

TIME	EVENT
3:30 p.m.	An overview of the DTRA-CB/JSTO biodosimetry program K. Herring, PhD Defense Threat Reduction Agency, Chemical and Biological Technologies Directorate (DTRA-CB), Joint Science and Technology Office (JSTO) at Fort Belvoir, Virgnia
3:50 p.m.	Overview of NIH/NIAID biodosimetry program: Research and development of biodosimetry techniques and devices N. Ramakrishnan, PhD Radiation/Nuclear Countermeasure Program, Division of Allergy, Immunology and Transplantation (NIAID), National Institutes of Health, Department of Health and Human Services in Bethesda, Maryland
4:10 p.m.	Biodosimetry challenges in radiological and nuclear incidents: Initiatives within the HHS Office of the Assistant Secretary for Preparedness and Response M. Grace, PhD Project Officer, BARDA CBRN Medical Countermeasures Division
4:30 p.m.	Federal Agency BD Program Manager (TBD)
4:50 p.m.	Concluding remarks COL M.A. Melanson, PhD Armed Forces Radiobiology Research Institute in Bethesda, Maryland
5:10 p.m.	Adjourn

Contact symposium chairman, Dr. William F. Blakely (william.blakely@usuhs.edu). Questions also may be directed to BDSymposium@afrri.usuhs.mil.