2012 seminar schedule

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2012 AFRRI Seminars
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Venue
Time: 10:30 to 11:30 a.m. (unless otherwise noted) each Friday Place: AFRRI Conference Room, unless otherwise indicated.
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Seminars are presented by AFRRI researchers and other members of the scientific community. While some seminars are open to the public, others are limited to specific audiences. Any exceptions to time, place, and admittance are noted with each item. We do not record or distribute information presented in our Seminar Program. However, where available, references to related information are provided with the seminar title.
2012 seminar schedule
Friday December 21: Sanchita P. Ghosh, PhD, Research Biologist, Radiation Countermeasures Program, AFRRI: Review of gamma-tocotrienol, a radiation prophylaxis agent. Related information: Gamma-tocotrienol, a radiation prophylaxis agent, induces a high level of granulocyte colony-stimulating factor. Int Immunopharmacol. 14:495–503, 2012. Hematological targets of radiation damage. Curr Drug Targets. 11:1375–1385, 2010. Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. Radiat Res. 173:738–747, 2010. Friday, December 14: Michael Abend, Prof. Dr. med. M.Sc./Colonel (MC), Deputy Director, Bundeswehr Institute of Radiobiology, Neuherbergstr 11, 80937 Munich, Germany: NATO biodosimetry study—Comparison of established and emerging biodosimetry assay. Related information: Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal tissues following the chernobyl accident. PLoS ONE 7:e39103, 2012. Common genetic variants related to genomic integrity and risk of papillary thyroid cancer. Carcinogenesis 32:1231–1237, 2011. Micro-RNA expression in cisplatin resistant germ cell tumor cell lines. Mol. Cancer 15:10–51, 2011. Friday, December 7: LT Joshua M. Swift, PhD, Combined Injury Program, AFRRI: Bad to the bone: Radiation and combined injury effects on skeletal tissue. Related information: Restriction of dietary energy intake has a greater impact on bone integrity than does restriction of calcium in exercising female rats. J Nutr. 142:1038–1045, 2012. Simulated resistance training, but not alendronate, increases cortical bone formation and suppresses sclerostin during disuse. J Appl Physiol. 112:918–925, 2012. Increased training loads do not magnify cancellous bone gains with rodent jump resistance exercise. J Appl Physiol. 109:1600–1607, 2010. Friday, November 30: Edward J. Calabrese, Professor, University of Massachusetts, School of Public Health and Health Sciences, Amherst, MA: Chemical and radiation hormesis: Toxicological foundations and biomedical applications. Related information: Hormesis: Its impact on medicine and health. Hum Exper Toxicol. 2012 Oct 11. [Epub ahead of print]. A method to evaluate hormesis in nanoparticle dose-responses. Dose Response. 10:344–354, 2012. Hormesis: Improving predictions in the low-dose zone. Mol Clin Environ Toxicol. 101:551–564, 2012. Friday, November 9: Mang Xiao, MD, Research Biologist, Radiation Countermeasures Program, AFRRI: Updated studies: Radioprotective effects of delta-tocotrienol and serum microRNA30c levels in gamma-irradiated mice. Related information: REDD1 protects osteoblast cells from gamma radiation-induced premature senescence. PLoS ONE 7:e36604, 2012. δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Haematologica 95:1996–2004, 2010. Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury. Exp Hematol. 37:52–64, 2009. Friday, November 2: Shilpa Kulkarni, PhD, Staff Investigator, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): Development of gamma-tocotrienol as a radiation countermeasure. Related information: Pentoxifylline enhances the radioprotective properties of gamma-tocotrienol: Differential effects on hematopoietic, gastrointestinal and vascular systems. Radiat Res. 175:297–306, 2011. Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total body irradiation. Radiat Res. 173:738–747, 2010. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Intl J Rad Biol. 85:598–606, 2009. Friday, October 26: Alexandra C. Miller, PhD, Senior Research Scientist, Radiation Countermeasures Program, AFRRI: Radiation leukemia: Genetic and epigenetic mechanisms. Related information: Radioprotection by the histone deacetylase inhibitor phenylbutyrate. Radiat Environ Biophys. 50:585–96, 2011. Preconceptional paternal exposure to depleted uranium: Transmission of genetic damage to offspring. Health Phys. 99:371–379, 2010. DNA methylation during depleted uranium-induced leukemia. Biochimie. 91:1328–1330, 2009. Friday, September 14: Regina Marie Day, PhD, Associate Professor, Department of Pharmacology, School of Medicine, USUHS: Captopril mitigates radiation effects in a murine model of dual hematopoietic and pulmonary injuries. Related information: Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation. Exp Hematol., 39:293–304, 2011. Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms. Am J Physiol Lung Cell Biol. 301:L772–L781, 2011. Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation. Exp Hematol. 38:270–281, 2010. Friday, September 7: Brian E. Livingston, Capt, USAF, BSC, Military Medical Operations, AFRRI: Bringing AFRRI to the troops: MMO readiness and outreach. Friday, August 24: Mr. Barrett N. Fountos, MS, Program Manager/Health Scientist, Office of Domestic and International Health Studies, U.S. Department of Energy, Germantown, MD: Recent research results from the Russian Health Studies Program. Related information: Editorial: The Department of Energy’s Russian Health Studies Program. Health Physics 93:187–189, 2007. Friday, July 6: Merriline M. Satyamitra, PhD, Research Scientist (HMJF), Radiation Countermeasures Program, AFRRI: The NIAID-AFRRI radiation countermeasure screening program. Related Information: A TPO receptor agonist, ALXN4100TPO, mitigates radiation-induced lethality and stimulates hematopoiesis in CD2F1 mice. Radiat Res. 175:746–758, 2011. Hematopoietic recovery and amelioration of radiation-induced lethality by the vitamin E isoform, δ-tocotrienol. Radiat Res. 175:736–745, 2011. Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells. Mol Cancer Ther. 5:1504–1510, 2006. Friday, June 22: Caroline H. Johnson, PhD, Postdoctoral Fellow, Laboratory of Metabolism, National Cancer Institute, NIH: Metabolomics for the discovery of urinary biomarkers of ionizing radiation exposure in non-human primates. Related information: Challenges and opportunities of metabolomics. J Cell Physiol. 227:2975–2981, 2012. Xenobiotic metabolomics: Major impact on the metabolome. Ann Rev Pharmacol Toxicol. 52:37–56, 2012. Radiation metabolomics 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats. Radiat Res. 175:473–484, 2011. Friday, June 8: Carl A. Curling, ScD; Research Staff Member; Strategy, Forces and Resources Division; Institute for Defense Analyses, Alexandria, VA: CBRN casualty estimation. Related information: A new methodology for estimating nuclear casualties as a function of time. Health Phys. 101:286–298, 2011. Overview of hazard assessment and emergency planning software of use to RN first responders. Health Phys. 97:145–156, 2009. Optimization of filtration for reduction of lung dose from radon decay product: Part I—Theoretical, Health Phys. 59:277–275, 1990; and Part II—Experimental. Health Phys. 59:277–285, 1990. Friday, June 1: Maria Moroni, PhD, Research Associate (Henry M. Jackson Foundation), Radiation Countermeasures Program, AFRRI: Efficacy of G-CSF administration and identification of an accelerated bone marrow syndrome in a minipig model of ARS. Related information: Hematological changes as prognostic indicators of survival: Similarities between Gottingen minipigs, humans, and other large animal models. PLoS ONE 6: e25210, 2011. Hematopoietic radiation syndrome in the Gottingen minipig. Radiat Res. 176:89–101, 2011 Vascular access port implantation and serial blood sampling in a Gottingen minipig (Sus scrofa domestica) model of acute radiation injury. J Am Assoc Lab Anim Sci. 50:65–72, 2011. Friday, May 18: Xinyue Lu, MD, PhD, Research Scientist (Henry M. Jackson Foundation), Radiation Countermeasures Program, AFRRI: Radioprotective effect of 17-DMAG in mice. Related Information: Inhibition of inducible nitric oxide synthase protects human T cells from chemical hypoxia-induced apoptosis. Mol Pharmcol. 73:738–747, 2008. Geldanmaycin inhibits hemorrhage-induced increases in caspase-3 activity: A role of inducible nitric oxide synthase. Am J Physiol. 103:1045–1055, 2007. Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line. J Biol Chem. 281:34341–34348, 2006. Friday, May 11: Zheng Wang, PhD, Research Biologist, Naval Research Laboratory, Washington, DC: Transcriptomic analysis reveals adaptation of the black yeast to the low dose of ionizing radiation. Related information: Draft genome sequence of the shrimp pathogen Vibrio harveyi CAIM 1792. J Bacteriol. 194:2104, 2012. Identification of non-coding RNAs in environmental vibrios. Microbiology 156:2452–2458, 2010. Comparative genomic analyses identify the Vibrio havehi genome sequenced strains BAA-1116 and HY01 as Vibrio campbellii. Environ Microbiol Rep. 2:81–89, 2010. Friday, April 27: Kushal Chakraborty, PhD, Staff Investigator (Henry M. Jackson Foundation), Radiation Countermeasures Program, AFRRI: Combined effect of GT3 and simvastatin on radiation induced hematopoietic injury. Related information: The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. J Biol Chem. 283:23048–23061, 2008. The role of nitric oxide in aspirin induced thrombolysis in vitro and the purification of aspirin activated nitric oxide synthase from human blood platelets. Am J Hematol. 82: 986–995, 2007. Restoration by aspirin of impaired plasma maspin level in human breast cancer. Acta Oncologica 45:184–187, 2006. Friday, April 20: Gregory L. King, PhD, Research Physiologist, Radiation Countermeasures Program, AFRRI: Acute response to space radiation: Prodromal syndrome in ferrets. Related information: 5-HT3 receptor antagonists ameliorate emesis in the ferret evoked by neutron or proton radiation. Aviat Space Environ Med. 70:485–492, 1999. Plasticity of autonomic control of emesis in irradiated ferrets. Am J Physiol. 265: R1092–R1099, 1993. Characterization of radiation-induced emesis in the ferret. Radiat Res. 114:599–612, 1988. Friday, April 13: Risaku Fukumoto, PhD, Research Associate, Henry M. Jackson Foundation (Radiation Combined Injury Program, AFRRI): Ciprofloxacin: Not just an antimicrobial. Related information: Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation. Radiat Res. 176:333–345, 2011. In vivo genetic mutations define predominant functions of the human T-cell Leukemia/Lymphoma Virus p12I protein. Blood 113:3726–3734, 2009. Inhibition of TCR signal transduction and viral expression by the linker for activation of T cells-interacting p12I protein of HTLV-1. J. Virol. 81:9088–9099, 2007. HTLV-1-encoded p30^II is a post-transcriptional negative regulator of viral replication. Nat Med. 10:197-201, 2004 Friday, April 6: Cam T. Ha, PhD, Research Scientist, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): Genistein inhibits radiation-induced inflammation and protects mouse hematopoietic tissue. Related information: Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis. Biol Reproduction 83:7–35, 2010. Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming growth factor beta 1 and vascular endothelial growth factor A in cells types involved in vascular remodeling in pregnancy. Biol Reprod. 79:1054–1061, 2008. N-glycosylation is required for binding of murine pregnancy-specific glycoproteins 17 and 19 to the receptor CD9. Am J Reprod Immunol. 59:251–258, 2008. Friday, March 30: Thomas B. Elliott, PhD, Research Microbiologist, Combined Injury Program, AFRRI: Procalcitonin as a biomarker to detect radiation-induced sepsis in mice and to monitor therapy. Related information: Real-time telemetric monitoring in whole-body 60Co gamma-photon irradiated rhesus macaques (Macaca mulatta). J Med Primatol. 39:399–407, 2010. Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection. Radiat Res. 173:319–332, 2010. Combined injury: Factors with potential to impact radiation dose assessments. Health Phys. 98:145–152, 2010. Friday, March 16: Mark H. Whitnall, PhD, Program Advisor, Radiation Countermeasures Program, AFRRI: Gottingen minipig model of acute radiation syndrome (ARS). Related information: Vascular access port implantation and serial blood sampling in a Gottingen minipig (Sus scrofa domestica) model of acute radiation injury. J Am Assoc Lab Anim Sci. 5:65–72, 2011. Hematopoietic radiation syndrome in the Gottingen minipig. Radiat Res. 176:89–101, 2011. Hematological changes as prognostic indicators of survival: Similarities between Gottingen minipigs, humans, and other large animal models. PLoS ONE 6:e25210. doi:10.1371/journal.pone.0025210, 2011. Friday, March 9: Lynnette Cary, PhD, Staff Scientist (Henry M. Jackson Foundation), Radiation Countermeasures Program, AFRRI: Endothelial cell regulation of hematopoietic cells after radiation injury. Related information: Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection. Radiat Res. 173:319–332, 2010. COX-2 inhibitors are contraindicated for treatment of combined injury. Radiat Res. 172:686–697, 2009. Epidermal growth factor receptor pathway substrate 8 (Eps8) is over expressed in human pituitary tumors: Role in proliferation and survival. Endocrinology 150:2064–2071, 2009. Friday, March 2: Michael R. Landauer, PhD, Research Toxicologist, AFRRI: Isoflavone-induced radiation protection: Current status. Related information: Captopril modulates HIF-1α and erythropoietin responses in a murine model of total body irradiation. Expt Hematol. 39:293–304, 2011. Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation. Expt Hematol. 38: 270–281, 2010. History and development of radiation-protective agents. Intl J Radiat Biol. 85:539–573, 2009. Friday, February 24: William F. Blakely, PhD, Program Advisor, Biological Dosimetry, AFRRI: Update on translational biodosimetry research activities. Related information: Optimization of calyculin A-induced premature chromosome condensation assay for chromosome aberration studies. Cytometry 79:1016–1022, 2011. Q(γ-H2AX), an analysis method for partial-body radiation exposure using γ-H2AX in nonhuman primate lymphocytes. Radiat Meas. 46:877–881, 2011. The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates. PLoS One 5:e15544, 2010. Friday, February 17: Joel Lowy, PhD, Principal Investigator, AFRRI: Responses of innate immune system cells to combined exposure to radiation and PAMPs. Friday, February 10: Natalia I. Ossetrova, PhD, Research Biologist, Biological Dosimetry Program, AFRRI: Further evaluation of combined proteomic and hematological approach for biodosimetry applications. Related information: Multiple parameter radiation injury assessment using a nonhuman primate radiation model—biodosimetry applications. Health Physics J. 98:153–159, 2010. Combined approach of hematological biomarkers and plasma protein SAA for improvement of radiation dose assessment in triage biodosimetry applications. 2010. Health Physics J. 98: 204–208, 2010. Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model. Intl J Rad Biol. 85:837–850, 2009. Friday, February 3: MAJ Eric D. Lombardini, VMD, Chief, Division of Comparative Pathology, Veterinary Sciences Department, AFRRI: Tissue collection for histopathology in various laboratory species. Related information: Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta). J Med Primatol. 39:315–317, 2010. Effect of resuscitation with 21% oxygen and 100% oxygen on NMDA receptor binding characteristics following asphyxia in newborn piglets. Neurochem Res. 32:1322–1328, 2007. Response to carbon dioxide by the infective larvae of three species of parasitic nematodes. Parasitol Int. 51:53–62, 2002. Friday, January 20: Nikolai Gorbunov, PhD, Henry M. Jackson Foundation (Combined Injury Program, AFRRI), Bethesda, MD: Response of mouse mesenchymal stromal cells (MSCs) to challenge with Escherichia coli: A proposed defense role of MSCs in the tissue barriers. Related information: Response of crypt paneth cells in the small intestine following total-body gamma-irradiation. Int J Immunopathol Pharmacol. 23:971–983, 2010. Radiation combined injury: DNA damage, apoptosis, and autophagy. Adaptive Medicine 2:1–10, 2010. Cardioprotection by adaptation to ischemia augments autophagy in association with BAG-1 protein. J Cell Mol Med 13:373–387, 2010. Friday, January 13: Juliann G. Kiang, PhD, Program Advisor, Combined Injury Program, AFRRI: Ciprofloxacin as a drug to treat radiation combined injury. Related information: Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat shock protein 90 kDa after ionizing radiation. Radiat Res. 176:333–345, 2011. Radiation combined injury: DNA damage, apoptosis, and autophagy. Adapt Med. 2:1–10, 2010. Wound trauma increases radiation-induced mortality by increasing iNOS, cytokine concentrations, and bacterial infections. Radiate Res. 173:319–332, 2010.
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