2010 seminar schedule

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2010 AFRRI Seminars
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Time: 10:30 to 11:30 a.m. (unless otherwise noted) each Friday Place: AFRRI Conference Room, unless otherwise indicated.
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Seminars are presented by AFRRI researchers and other members of the scientific community. While some seminars are open to the public, others are limited to specific audiences. Any exceptions to time, place, and admittance are noted with each item. We do not record or distribute information presented in our Seminar Program. However, where available, references to related information are provided with the seminar title.
2010 seminar schedule
Friday, December 17: Nikolai Gorbunov, PhD, Research Associate Professor, Henry M. Jackson Foundation (Combined Injury Program, AFRRI): Therapy effects of mesenchymal stromal cells in mouse model of radiation combined injury. Related information: Radiation combined injury: DNA damage, apoptosis, and autophagy. Adaptive Medicine 2:1–10, 2010. Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation. J Pathol. 219:242–252, 2009. Cardioprotection by adaptation to ischemia augments autophagy in association with BAG-1 protein. J Cell Mol Med. 13:373–387, 2008. Friday, December 10 (10–11 a.m.): Xinyue Lu, MD, PhD, Research Scientist (HMJF), Radiation Countermeasures Program, AFRRI: Human decay accelerating factor attenuates the CRP-augmented murine tissue injury after mesenteric ischemia/reperfusion. Related Information: Inhibition of inducible nitric oxide synthase protects human T cells from chemical hypoxia-induced apoptosis. Mol Pharmcol. 73:738–747, 2008. Geldanmaycin inhibits hemorrhage-induced increases in caspase-3 activity: Role of inducible nitric oxide synthase. Am J Physiol. 103:1045–1055, 2007. Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line. J Biol Chem. 281:34341–34348, 2006. Friday, December 3: Christophe E. Redon, PhD, Research Fellow, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md.: Gamma-H2AX as a biodosimeter for ionizing radiation exposure: An in vivo study with non-human primates. Related Information: DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions. Cell Cycle 9:274–278, 2010. Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. EMBO J. 28:3667–3680, 2009. H2AX: Functional roles and potential applications. Chromosoma. 118:683–692, 2009. Friday, November 19: Ikuo Kashiwakura, PhD, Professor, Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan: Radiosensitivity of human hematopoietic stem/progenitor cells. Related information: Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells. Radiat Res. 174:177–184, 2010. Correlations of cell surface antigens with individual differences in radio-sensitivity in human hematopoietic stem/progenitor cells. Radiat Res. 173:184–90, 2010. Radiation sensitivities in the terminal stages of megakaryocytic maturation and platelet production. Radiat Res. 172, 314–320, 2009. Friday, November 12: Mang Xiao, MD, Research Biologist, Radiation Countermeasures Program, AFRRI: Characteristics of REDD1, a novel stress response gene, in ionizing radiation-induced human and mouse hematopoietic and osteoblast cell survival and apoptosis. Related information: δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through Erk/mTOR signaling. Haematologica.2010; 95:xxx [Epub ahead of print]. doi:10.3324/haematol.2010.026492 Pharmacological countermeasures for the acute radiation syndrome. Curr Mol Pharmacol. 2 :122–133, 2009. Role of NF-κB in hematopoietic niche function of osteoblasts after radiation injury. Exp Hematol. 37:52–64, 2009. Friday, November 5: Glen I. Reeves, MD, Life Sciences Section Manager, TASC, Advisory and Assistance Services to Defense Threat Reduction Agency, Lorton, Va.: Medical implications of enhanced radiation weapons. Related information: New human data versus estimates of effects of inhaling fission product mixtures. Health Phys. 90:1–4, 2009. Medical treatment of radiation injuries—Current U.S. status. Radiation Measurements 42:1063–1074, 2007. Description of the chronic radiation syndrome in humans irradiated in the former Soviet Union. Radiat Res. 142: 242–244, 1995. Friday, October 29 (10–11 a.m.): Alexandra C. Miller, PhD, Senior Research Scientist, Radiation Countermeasures Program, AFRRI: Phenylbutyrate, a novel radiation countermeasure: Radiation protection, radiation mitigation, and leukemia prevention. Related information: Preconceptional paternal exposure to depleted uranium: Transmission of genetic damage to offspring. Health Phys. 99:371–379, 2010. A review of depleted uranium biological effects: In vitro and in vivo studies. Rev Environ Health. 22:75–89, 2007. Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium. Mol Cell Biol. 279:97–104, 2005. Friday, October 22: Shamila Yusuff, PhD, formerly Post Doctoral Fellow, Johns Hopkins University, Md.: Zebrafish as a model for biomedical research. Related information: Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech Dev. 126:898–912, 2009. Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genet. 4:e1000240, 2008. Developmental expression of functional cyclooxygenase in zebrafish. Proc Natl Acad Sci USA. 99:8418–8423, 2002. Friday, October 15: Prabhat C. Goswami, PhD, Associate Professor, Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa: Late ROS accumulation and radiation response. Related information: Mild hyperthermia as a potential mechanism to locally enhance cell growth kinetics. J Drug Target. 17:719–723, 2009. Polychlorinated biphenyl (PCB)-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free Rad Biol Med. 47:1762–1771, 2009. Mitochondrial ROS and radiation-induced transformation in mouse embryonic fibroblasts. Cancer Biol Ther. 8:1962–1971, 2009. Friday, October 8: Merriline M. Satyamitra, PhD, Research Scientist (HMJF), Radiation Countermeasures Program, AFRRI: The NIAID-AFRRI radiation countermeasure screening program. Related information: Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells. Mol Cancer Ther. 5:1504–1510, 2006. Tracing radiation-induced genomic instability in vivo in the haemopoietic cells from fetus to adult mouse. Br J Radiol. 78:928–933, 2005. Protection against prenatal irradiation-induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin. Int J Radiat Biol. 80:653–662, 2004. Friday, October 1: Michael Abend, Prof. Dr. Med. M.Sc./Colonel (MC), Deputy Director, Bundeswehr Institute of Radiobiology, Munich, Germany: Early-phase hematological changes taken from accidentally radiation-exposed individuals predict the later occurring ARS severity score. Related information: Radiation-induced late effects in two affected individuals of the Lilo radiation accident. Radiat Res. 167:615–623, 2007. Intercellular adhesion molecule-1: A consistent inflammatory marker of the cutaneous radiation reaction both in vitro and in vivo. Br J Dermatol. 155:670–679, 2006. Comparison of endogenous TP53 genomic status with clonogenicity and different modes of cell death after X- irradiation. Radiat Res. 161:39–47, 2004 Friday, September 17: Juliann G. Kiang, PhD, Program Advisor, Combined Injury Program, AFRRI; Professor of Radiation Biology, Pharmacology, and Medicine, School of Medicine, USUHS: Radiation combined injury: DNA damage, apoptosis, and autophagy. Related information: Radiation combined injury: DNA damage, apoptosis, and autophagy. Adapt Med., 2:1–10, 2010. Wound trauma increases radiation-induced mortality by increasing iNOS pathway and elevation of cytokine concentrations and bacterial infection. Radiat Res. 173:319–332, 2010. COX-2 inhibitors are contraindicated for treatment of combined injury. Radiat Res. 172: 686–697, 2009. Friday, September 10: MAJ Eric D. Lombardini, VMD, Chief, Division of Comparative Pathology, Veterinary Sciences Department, AFRRI: Fish in research: Models and pathology. Related information: Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta). J Med Primatol. 2010 [Epub ahead of print] Effect of resuscitation with 21% oxygen and 100% oxygen on NMDA receptor binding characteristics following asphyxia in newborn piglets. Neurochem Res. 32:1322–1328, 2007. Response to carbon dioxide by the infective larvae of three species of parasitic nematodes. Parasitol Int. 51:53–62, 2002. Friday, August 20: Sanchita P. Ghosh, PhD, Research Biologist, Radiation Countermeasures Program, AFRRI: Molecular paradox: Gene regulation of TNF receptor associated factors (Traf-1 and Traf-3) as possible mechanism of radioprotection by GT3. Related information: Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. Radiat Res. 173:738–747, 2010. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol. 85:598–606, 2009. Radiation protection by a new chemical entity, Ex-Rad: Efficacy and mechanisms. Radiat Res. 171:173–179, 2009. Friday, August 13: CDR Colleen Walker Gilstad, MD, Staff Pathologist, National Naval Medical Center, Bethesda, Md.: Military operations transfusion support and associated risk of graft versus host disease. Related information: Case report: Moderate hemolytic disease of the newborn due to anti-G. Immunohematology 22:166–170, 2006. Anaphylactic transfusion reactions. Curr Opin Hematol. 10:419–423, 2003. Transfusing patients with anti-immunoglobulin A subclass antibodies. Vox Sang. 83:363, 2002. Friday, August 6: Jennifer M. Mitchell, VMD, Clinical Veterinarian, Henry M. Jackson Foundation (Veterinary Sciences Department, AFRRI): Fundamentals of laboratory animal anesthesia and analgesia. Friday, July 30: MAJ Eric D. Lombardini, VMD, Chief, Division of Comparative Pathology, Veterinary Sciences Department, AFRRI: Zoonoses and laboratory animals, epidemiology and pathological lesions of laboratory animals from fish to non-human primates (and everything in-between). Related information: Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta). J Med Primatol. 2010 [Epub ahead of print] Effect of resuscitation with 21% oxygen and 100% oxygen on NMDA receptor binding characteristics following asphyxia in newborn piglets. Neurochem Res. 32:1322–1328, 2007. Response to carbon dioxide by the infective larvae of three species of parasitic nematodes. Parasitol Int. 51:53–62, 2002. Friday, July 23: Albert Dobi, PhD, Assistant Director, Basic Science Research Program, Chief, Section for Gene Regulation and Bioinformatics, Center for Prostate Disease Research, Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Md.: ERG oncoprotein, a result of genomic fusion events, reveals the clonal origin of prostate tumors. Related information: Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells. Oncogene 29:2457–2466, 2010. Prostate cancer risk allele specific for African descent associates with pathologic stage at prostatectomy. Cancer Epidemiol Biomarkers Prev. 19:1–8, 2010. Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons. J Neurosci. 30:218–229, 2010. Friday, July 16: Raj K. Puri, MD, PhD, Director, Division of Cellular and Gene Therapies; Chief, Tumor Vaccines and Biotechnology Branch, Center for Biologics Evaluation and Research, FDA, National Institutes of Health, Bethesda, Md.: Targeting IL-13 receptor tumor antigen for cancer therapy. Related information: A novel role of interleukin-13 receptor a2 in pancreatic cancer invasion and metastasis. Cancer Res. 69:8678–8685, 2009. Overexpression of interleukin-13 receptor-a2 as a novel therapy for malignant pheochromocytoma: A novel target for receptor directed anti-cancer therapy. J Clin Endocrinol Metab. 94: 2952–2957, 2009. IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma. Int J Cancer 124:1440–1448, 2009. Friday, July 9: Vijay K. Singh, PhD, Radiation Countermeasure Program, AFRRI, Department of Radiation Biology, F. Edward Hebért School of Medicine, USUHS: CBLB502: A promising radiation countermeasure. Related information: Preclinical development of a bridging therapy for radiation casualities. Exp Hematol. 38:61–70, 2010. Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor. Int J Rad Biol. 86:12–21, 2010. Tocopherol succinate: A promising radiation countermeasure. Int Immunopharmacol. 9:1423–1430, 2009. Friday, July 2: Barbara Fei Ngudiankama, PhD, Research Associate, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): The role of cypin in dendrite patterning. Related information: Activity-independent regulation of dendrite patterning by postsynaptic density protein PSD-95. J Neurosci. 26:10164–10176, 2006. A novel role for snapin in dendrite patterning: Intercation with cypin. Mol Biol Cell. 16:5103–5114, 2005. Cypin regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly. Nature Neurosci. 7:145–152, 2004. Friday, June 25: Thomas J. MacVittie, PhD, Professor, University of Maryland School of Medicine, Departments of Radiation Oncology and Pathology, Baltimore, Md.: Acute and delayed effects of the ARS: An animal model research platform to assess efficacy of medical countermeasures. Related information: Products of anti-DC3/antio-CD28 activated lymphocytes induce differentiaion and maturation of dendritic cells and has adjuvant-like activity in vitro and in vivo. Clin Immunol. 129:58–68, 2008. The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6-Gy whole-body radiation model. Radiation Measurements. 42: 1158–1163, 2007. Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after non-myeloablative transplantation with transduced autologous peripheral blood progenitor cells. Molecular Therapy 14:202–211, 2005. Friday, June 18: Cam T. Ha, PhD, Research Scientist, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): Pregnancy specific glycoproteins (PSGs) have potential roles in immune-modulation and placental vascular morphogenesis. Related information: Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming growth factor beta 1 and vascular endothelial growth factor A in cells types involved in vascular remodeling in pregnancy. Biol Reprod. 79:1054–1061, 2008. N-glycosylation is required for binding of murine pregnancy-specific glycoproteins 17 and 19 to the receptor CD9. Am J Reprod Immunol. 59:251–258, 2008. Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1. J Leukoc Biol. 77:948–957, 2005. Friday, June 11 (9:30–11:30): MAJ Larry J. Shelton, DVM, MPH, Head, Veterinary Sciences Department, AFRRI: Conquering the DoD animal protocol. Friday, May 28: Samitabh Chakraborti, PhD, Post-Doctoral Fellow, Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, USU: Protein-protein interactions in viral entry and intervention. Related information: Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies. Proc Natl Acad Sci USA 104:12123–12128, 2007. Potent knock down of HIV-1 replication by targeting HIV-1 Tat/Rev RNA sequences synergistically with catalytic RNA and DNA. AIDS 21:31–40, 2007. Development of human monoclonal antibodies against diseases caused by emerging and biodefense-related viruses. Expert Rev Anti Infect Ther. 4:57–66, 2006. Friday, May 21: Jasleen Shant, PhD, Postdoctoral Fellow, Henry M. Jackson Foundation (Biological Dosimetry Program, AFRRI): Akt-dependent NF-kappaB activation is critical for deoxycholyltaurine to rescue human colon cancer cells from stress-induced apoptosis. Related information: Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol. 296:G755–G763, 2009. Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Exp Cell Res. 315:432–450, 2008 Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol. 295:G591–G597. Friday, May 14: Joel Lowy, PhD, Principal Investigator, AFRRI: Cell signaling puzzle: Macrophage response to influenza virus, LPS, and radiation. Friday, May 7: William F Blakely, PhD, Program Advisor, Biological Dosimetry, AFRRI: Biological dosimetry—Early phase response. Related information: Combined approach of hematological biomarkers and plasma protein SAA for improvement of radiation dose assessment triage in biodosimetry applications. Health Phys. 98:204–208, 2010. Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications. Health Phys. 98:153–159, 2010. Multiple blood-proteins approach for early-response exposure assessment using an in vivo murine radiation model. Int J Radiat Biol. 85:837–850, 2009. Friday, April 30: Graca D. Almeida-Porada, MD, PhD, Professor of Animal Biotechnology, Cell and Molecular Biology and Immunology, University of Nevada, Reno, Nev.: Endothelial progenitor cells for cell therapies. Related information: Persistent circulating human insulin in sheep transplanted in utero with human mesenchymal stem cells. Exp Hematol. 38:311–320, 2010. Generation of tissue-specific cells from MSC does not require fusion or donor-to-host mitochondrial/membrane transfer. Stem Cell Res. 2:125–138, 2009. Development and characterization of a novel CD34 monoclonal antibody that identifies sheep hematopoietic stem/progenitor cells. Exp Hematol. 36:1739–1749, 2008. Friday, April 23: Ashima Saxena, PhD, Chief, Department of Structural & Molecular Biology, Division of Bacterial & Rickettsial Diseases, Walter Reed Army Institute of Research, Silver Spring, Md.: Developing bioscavengers for the prophylaxis of nerve agent toxicity. Related information: Efficacy of human serum butyrylcholinesterase against sarin vapor. Chem Biol Interact. 175:267–272, 2008. Comparison of oxime reactivation and aging of nerve agent-inhibited monkey and human acetylcholinesterases. Chem Biol Interact. 175:261–266, 2008. An in vitro comparative study on the reactivation of nerve agent-inhibited guinea pig and human acetylcholinesterases by oximes. Biochemistry 46:11771–11779, 2007. Friday, April 9: Thomas B. Elliott, PhD, Research Microbiologist, Combined Injury Program, AFRRI: Combined therapy for wound infection in mixed-field-neutron-irradiated mice. Related information: Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection. Radiat Res. 173:319–332, 2010. Combined injury: factors with potential to impact radiation dose assessments. Health Phys. 98:145–152, 2010. COX-2 inhibitors are contraindicated for treatment of combined injury. Radiat Res. 172:686–697, 2009. Friday, March 26: Gregory L. King, PhD, Research Physiologist, Biodosimetry Program, AFRRI: The prodromal phase of the ARS to varied irradiation qualities in the ferret model. Related information: 5-HT3 receptor antagonists ameliorate emesis in the ferret evoked by neutron or proton radiation. Aviat Space Environ Med. 70:485–492, 1999. Plasticity of autonomic control of emesis in irradiated ferrets. Am J Physiol. 265: R1092–R1099, 1993. Characterization of radiation-induced emesis in the ferret. Radiat Res. 114:599–612, 1988. Friday, March 19: G. David Ledney, PhD, Research Biologist, Combined Injury Program, AFRRI: Combined injury: γ-photon and mixed-field irradiations, trauma, infection and selected countermeasures. Related information: Combined injury: factors with potential to impact radiation dose assessments. Health Physics 98: 145–152, 2010. Resident bacteria in a mixed population of rhesus macaque (Macaca mulatta) monkeys: a prevalence study. J Med. Primatology 38:397–403, 2009. COX-2 inhibitors are contraindicated for treatment of combined injury. Radiat Res.172:686–697, 2009. Friday, March 12: Julie L. Christensen, PhD, Group Leader-Cell Biology, Cellerant Therapeutics, San Carlos, Calif.: Development of ex vivo expanded allogeneic myeloid progenitors as a medical countermeasure for ARS. Related information: Prevention and reversal of autoimmune disease in lupus-prone NZB/NZW mice by transplantation of purified allogeneic hematopoietic stem cells. Blood 110:1370–1378, 2007. Loss of expression of the HOXA-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells. Blood 106:3988–3994, 2005. Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell 119:543–554, 2004. Friday, March 5: John F. Kalinich, PhD, Program Advisor, Internal Contamination and Metal Toxicity Program, AFRRI: Health effects of embedded metal fragments. Related information: The use of established skeletal muscle cell lines to assess potential toxicity from embedded metal fragments. Toxicology In Vitro 23:356–359, 2009. Protocol for the assessment of potential health effects from embedded metal fragments. Mil Med. 174:265–269, 2009. Urinary and serum metal levels as indicators of embedded tungsten alloy fragments. Mil Med. 173:754–758, 2008. Friday, February 26: Venkataraman Srinivasan, PhD, Research Biologist, Radiation Countermeasures Program, AFRRI: Mitochondrial metabolism and ionizing radiation: Preliminary studies. Related information: Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic, as a radiation countermeasure. Immunopharmacol Immunotoxicol. 30:271–290, 2008. Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxident gamma-tocotrienol. Life Sciences 78:2099–2104, 2006. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol. 23:379–385, 2003. Friday, February 19: K.S. Kumar, PhD, Research Chemist, Radiation Countermeasures Program, AFRRI: Further studies on gamma-tocotrienol. Related information: Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol. 85:598–606, 2009. Radiation protection by a new chemical entity, Ex-Rad™: efficacy and mechanisms. Radiat Res. 71:173–179, 2009. Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. Life Sci. 78:2099–104, 2006. Friday, February 12: Michael R. Landauer, PhD, Research Toxicologist, AFRRI: Radioprotective efficacy of genistein: Update. Related information: Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice. Int Immunopharmacol. 9:1401–1410, 2009. Genistein induces radioprotection by hematopoietic stem cell quiescence. Int J Radiat Biol, 84:713–726, 2008. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. J Radiat Res (Tokyo, 49:361–72, 2008. Friday, January 29: Mark H. Whitnall, PhD, Program Advisor, Radiation Countermeasures Program, AFRRI: Radiation countermeasure 5-androstenediol: Update. Related information: Role of NF-kappaB in hematopoietic niche function of osteoblasts after radiation injury. Exptl Hematol. 37:52–64, 2009 Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 30:271–290, 2008. Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expression. Exp Mol Pathol. 84:178–188, 2008. Friday, January 15: Shilpa Kulkarni, PhD, Research Associate, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): Radioprotective efficacy and molecular mechanisms of gamma tocotrienol alone and in combination with pentoxifylline. Related information: Gamma-tocotrienol, a tocol antioxidant as a potent radiation radioprotector. Intl J Rad Biol. 85:598–606, 2009. Radiation protection by a new chemical entity Ex-Rad™: efficacy and mechanisms. Radiation Research 171:173–179, 2009. Molecular basis for specific sub-cellular localization of C2 like domain of 5 lipoxygenase. J Biol Chem. 277:13167–74, 2002. Friday, January 8: Risaku Fukumoto, PhD, Research Associate, Henry M. Jackson Foundation (Radiation Combined Injury Program, AFRRI): 17-DMAG: A heat shock protein inhibitor as a potential candidate in radioprotection. Related information: In vivo genetic mutations define predominant functions of the human T-cell Leukemia/Lymphoma Virus p12I protein. Bloo, 113:3726-3734, 2009. Inhibition of TCR signal transduction and viral expression by the linker for activation of T cells–interacting p12(I)protein of HTLV-1. J. Virol. 81:9088-9099, 2007. HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat Med. 10:197-201, 2004.
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