2008 AFRRI Seminars

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Venue

Time: 11 a.m. to 12 noon (unless otherwise noted) each Friday
Place: AFRRI Conference Room, unless otherwise indicated.

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Seminars are presented by AFRRI researchers and other members of the scientific community. While some seminars are open to the public, others are limited to specific audiences. Any exceptions to time, place, and admittance are noted with each item. We do not record or distribute information presented in our Seminar Program. However, where available, references to related information are provided with the seminar title.

2008 seminar schedule

Friday, December 19: Shilpa Kulkarni, PhD, Staff Investigator, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI), Bethesda, Md.: Radioprotective efficacy of gamma-tocotrienol and pentoxyfylline. Related information:
- Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase. J Biol Chem. 277:13167–13174, 2002.
Friday, December 12: Eleanor A. Blakely, PhD, Senior Staff Biophysicist, Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, Calif.: Space radiation and cataracts. Related information:
- Synthetic nano-low density lipoprotein as targeted drug delivery vehicle for glioblastoma multiforme. Int J Pharm. 328:86–94, 2007.
- A review of ground-based heavy-ion radiobiology relevant to space radiation risk assessment: II. Cardiovascular and immunological effects. Adv Space Res. 40:461–469, 2007.
- A review of ground-based heavy ion radiobiology relevant to space radiation risk assessment: I. Cataracts and CNS effects. Adv Space Res. 40:1307–1319, 2007.
Friday, December 5: Gayle E. Woloschak, PhD, Professor, Department of Radiation Oncology, Department of Cell and Molecular Biology; Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Ill.: Studies of the effects of low dose rate radiation and radioprotectors on late tissue toxicities. Related information:
- X-ray fluorescence microprobe imaging in biology and medicine. J Cell Biochem. 99:1489–1502, 2006.
- Report on workshop of biological applications of X-ray microbeams. Intl J Radiat Biol. 78:749–752, 2002.
- Sensitivity to low-dose radiation in radiosensitive “wasted” mice. Mil Med. 167:42–44, 2002.
Friday, November 7: Adarsh Ramakumar, PhD, Senior Bioinformatics and Biomedical Engineering Analyst, Henry M. Jackson Foundation (Biological Dosimetry Program, AFRRI): Viral detection and discovery using pan-viral DNA micro-array: Design, development, implementation and analyses. Related information:
- Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp. strain BH72. Nature Biotechnology doi:10.1038/nbt1243, 2006.
Friday, October 24: Natalia I. Ossetrova, PhD, Research Assistant Professor, Henry M. Jackson Foundation (Biological Dosimetry Program, AFRRI): In vivo nonhuman primate dose-response for radiation dose assessment using protein expression profile. Related information:
- The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6-Gy whole-body radiation model. Radiation Measurements 42:1158–1163, 2007.
- Amylase and blood cell-count hematological radiation-injury biomarkers in a rhesus monkey radiation model—Use of multiparameter and integrated biological dosimetry. Radiation Measurements 42: 1164–1170, 2007.
- Ultra-high sensitivity multi-photon detection imaging in proteomics analyses. Proteomics 5:2322–2330, 2005.
Friday, October 17: Alexandra C. Miller, PhD, Senior Research Scientist, Radiation Countermeasure Program, AFRRI: Internalized uranium: An update on mechanisms, biomarkers, and alpha particles. Related information:
- A review of depleted uranium biological effects: in vitro and in vivo studies. Rev Environ Health 22:75–89, 2007.
- Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium: characterization of dose. Mol Cell Biol. 279:97–104, 2005.
- Suppression of depleted uranium-induced neoplastic transformation of human cells by the phenyl acid, phenyl acetate: chemoprevention by targeting the p21RAS protein pathway. Radiat Res. 155:163–170, 2001.
Friday, October 10: Mark H. Whitnall, PhD, Program Advisor, Radiation Countermeasures Program, AFRRI: New directions in radiation countermeasure research. This seminar is open only to AFRRI and contract employees posted at AFRRI. Related information:
- Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 30:271–290, 2008.
- Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expression. Exp Mol Pathol. 84:178–188, 2008.
- 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression. Mol Pharmacol. 72:370–379, 2007.
Friday, October 3: Kevin Camphausen, MD, Branch Chief, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health: Preclinical models in radiation oncology. Related information:
- Performing nondiagnostic research biopsies in irradiated tissue: a review of scientific, clinical, and ethical considerations. JCO 26:3987–3994, 2008.
- Safety and immunological response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant. Clincal Cancer Res. 14:5284–5291, 2008.
- Radiation-induced gene translation profiles reveal tumor type and cancer-specific components. Cancer Res. 68:3819–3826, 2008.
Friday, September 26: Maria Moroni, PhD, Research Associate, Henry M. Jackson Foundation (Biological Dosimetry Program, AFRRI): Automated cytogenetic biodosimetry sample processing protocol. Related information:
- Pattern of serum immunoreactivity against breast cancer cell lysates may predict severity of disease in breast cancer patients. Cancer Immunol Immunothe. 56:1711–1721, 2007.
- Progressive loss of syk and abnormal proliferation in breast cancer cells. Cancer Res. 64:7346–7354, 2004.
- Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway. Oncogene 22:7998–8011, 2003.
Friday, September 19: Wan Jiao, MD, PhD, Assistant Professor, Henry M. Jackson Foundation (Combined Injury Program, AFRRI): Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export. Related information:
- Aberrant nucleocytoplasmic localization of RB in human cancer correlates with moderate/poor tumor differentiation. Oncogene 27:3156–3164, 2008.
- Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export. J Biol Chem. 281:38098–38108, 2006.
- E2F-dependent repression of topoisomerase II regulates heterochromatin formation and apoptosis in cells with melanoma-prone mutation. Cancer Res. 65:4067–4077, 2005.
Friday, September 12: Janet Elizabeth Baulch, PhD, Assistant Professor, Radiation Oncology Research Laboratory, Radiation Oncology Department, School of Medicine, University of Maryland, Baltimore, Md.: The effect of low and high LET irradiations on DNA methylation and genomic instability. Related information:
- Epigenetic changes and nontargeted radiation effects—is there a link? Environmental and Molecular Mutagenesis 49:16–25, 2008.
- Interleukin 8 exhibits a pro-mitogenic and pro-survival role in radiation induced genomically unstable cells. Mutation Res. 640:74–81, 2008.
- Cytokine and chemokine responses after exposure to ionizing radiation: Implications for the astronauts. Adv Space Res. 39:1019–1025, 2007.
Friday, July 25: Adam N. Goldfarb, MD, Associate Director, Clinical Hematology Laboratory, Associate Professor, Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA: Regulatory Pathways in Erythroid and Megakaryocytic Differentiation. Related information:
- Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation. Cancer Lett. 251:179–186, 2007.
- Erythroid inhibition by the leukemic fusion AML1-ETO is associated with impaired acetylation of the major erythroid transcription factor GATA-1. Cancer Res. 66:2990–2996, 2006.
- Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2. Mol Cell Biol. 24:7779–7794, 2004.
Friday, July 18: Vijay K Singh, PhD, Department of Radiation Biology, F. Edward Hebért School of Medicine, Radiation Countermeasures Program, AFRRI: Cytokines as biomarkers for radiation countermeasures. Related information:
- Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expression. Exp Mol Pathol. 84:178–188, 2007.
- Induction of cytokines by radioprotective tocopherol analogs. Expt Mol Pathol. 81:55–61, 2006.
- Radioprotection by N-palmitoylated nonapeptide of human interleukin-1beta. Peptides 26:413–416, 2005.
Friday, June 27: Nikolai Gorbunov, PhD, Research Associate Professor, Henry M. Jackson Foundation (Combined Injury Program, AFRRI): Systemic response and vascular endothelium alterations in a model of shock wave induced traumatic injury. Related information:
- Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury. Free Radic Biol Med. 43:397–407, 2007.
- Spatial coordination of cell adhesion molecules and redox cycling of iron in the microvascular inflammatory response to pulmonary injury. Antioxid Redox Signal. 9:483–495, 2007.
- Pulmonary biochemical and histological alterations after repeated low-level blast overpressure exposures. Toxicol Sci. 95: 289–296, 2007.
Friday, June 13: Ana P. Cotrim, DDS, PhD, Researcher Fellow, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Md.: Mechanisms of damage, prevention and “recovery” of salivary glands from irradiation. Related information:
- Gene therapy: some history, applications, problems, and prospects. Toxicol Pathol. 36:97–103, 2008.
- Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands. Hum Gene Ther. 19:279–286, 2008.
- Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther. 15:2101–2106, 2007.
Friday, June 6: Ofer Levy, MD, PhD, Assistant Professor of Pediatrics, Division of Infectious Diseases, Children's Hospital, Harvard Medical School, Boston, Mass.: Role of endotoxin-directed innate immunity in radiation toxicity. Related information:
- Evidence of a bactericidal permeability increasing protein in an invertebrate, the Crassostrea gigas Cg-BPI. Proc Natl Acad Sci. 104:17759–17764, 2007.
- Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 204:2407–2422, 2007.
- Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease. Infect Immun. 75:342–349, 2007.
Friday, May 30: Kamal Datta, MD, Research Assistant Professor, Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC: DNA damage—Quality vs. quantity: Implications for repair, genomic stability, and radiochemoprophylaxis. Related information:
- Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML. Blood 111:3173–3182, 2008.
- Determination and analysis of site-specific 125-I decay-induced DNA double-strand break end-group structures. Radiat Res. 167:152–166, 2007.
- Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break. Radiat Res. 166:767–781, 2006.
Friday, May 16: Juliann G. Kiang, PhD, Senior Principal Investigator, Combined Injury Program, AFRRI: Inhibition of the iNOS pathway protects from ionizing radiation injury. Related information:
- Inhibition of inducible nitric oxide synthase protects human T cells from hypoxia-induced injury. Mol Pharmacol. 73:738–747, 2008.
- Androstenediol inhibits trauma-hemorrhage-induced increase in caspase-3 by downregulating inducible nitric oxide synthase pathway. J App Physiol. 102:933–941, 2007.
- Subpicosecond time-resolved Raman studies of field-induced transient transport in an In_xGa_1–x-based p-i-n semiconductor nanostructure. App Physics Lett. 89:262101, 2006.
Friday, May 9: Lynnette Cary, PhD, Scientist, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): The identification of genes involved in pituitary tumorigenesis. Related information:
- Bone morphogenetic protein and retinoic acid inducible neural specific protein-3 (BRINP3) is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration and invasion. J. Endocrinology 148:967–975, 2007.
- Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumors. Cancer Gene Ther. 13:993–1001, 2006.
- Stimulation through CD40 on mouse and human renal cell carcinomas triggers cytokine production, leukocyte recruitment, and antitumor responses that can be independent of host CD40 expression. J Immunol. 176:6543–6552, 2006.
Friday, May 2: Thomas B. Elliott, PhD, Research Microbiologist, Radiation Infection Treatment Program, AFRRI: Title to be announced. Related information:
- Antimicrobial therapy for bacillus anthracis-induced polymicrobial infection in ⁶⁰Co gamma-irradiated mice. Antimicrob Agents Chemother. 46:3463–71, 2002.
- Bacillus anthracis infection in irradiated mice: susceptibility, protection, and therapy. Mil Med. 167:103–104, 2002.
Friday, April 25: G. David Ledney, PhD, Research Biologist, Radiation Infection Treatment group, AFRRI: Combined Injury: Past, present, and future. Related information:
- Antibacterial activity of the soy isoflavone genistein. J Basic Microbiol. 46:329–335, 2006.
- Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without ⁶⁰Co gamma-photon irradiation. J Med Microbiol. 54:1157–1162, 2005.
- Clindamycin and quinolone therapy for Bacillus anthracis Sterne infection in ⁶⁰Co-gamma-photon-irradiated and sham-irradiated mice. J Antimicrob Chemother. 56:1074–1080, 2005.
Friday, April 18: Sanchita P. Ghosh, PhD, Research Investigator, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): Radiation protection profile of gamma-tocotrienol. Related information:
- The role of cysteines and charged amino acids in extracellular loops of the human Ca²⁺ receptor in cell surface expression and receptor activation processes. Endocrinology 145, 3892–3903, 2004.
Friday, April 11: Rupak Pathak, PhD, Post-Doctoral Research Associate, Henry M. Jackson Foundatiion (Biodosimetry Program, AFRRI: Heavy ion-induced nuclear damage in mammalian cell lines. Related information:
- Cell killing, nuclear damage and apoptosis in Chinese hamster V79 cells after irradiation with heavy-ion beams of (16)O, (12)C and (7)Li. Mutat Res. 632:58–68, 2007.
- Response to high LET radiation 12C (LET, 295 keV/microm) in M5 cells, a radio-resistant cell strain derived from Chinese hamster V79 cells. Int J Radiat Biol. 83:53–63, 2007.
- Genotoxic effects in M5 cells and Chinese hamster V79 cells after exposure to (7)Li-beam (LET=60 keV/microm) and correlation of their survival dynamics to nuclear damages and cell death. Mutat Res. 628:56–66, 2007.
Friday, April 4: Linda DeVeaux, PhD, Associate Professor of Cell Biology, Department of Biological Sciences, Idaho State University, Pocatello, ID, and Dr S. DasSarma, Professor, PhD, Director, Molecular Genetics, Genomics, & Bioinformatics Track, Molecular Medicine Program, University of Maryland, Baltimore, MD: Post-genomic analysis of a model extremophile: Radiation, repair, and expression of the DNA binding protein RPA in halobacterium. Related information:
- Extremely radiation-resistant mutants of a halophilic archaeon with increased single-stranded DNA-binding protein (RPA) gene expression. Radiat Res. 168:507–514, 2007.
- Transcriptional profiling of the model Archaeon Halobacterium sp. NRC-1: Responses to changes in salinity and temperature. Saline Systems 3:6, 2007.
- Molecular cloning and developmental expression of AtGR1, a new growth-related Arabidopsis gene strongly induced by ionizing radiation. Radiat Res. 154:355–364, 2000.
Wednesday, March 26: B.S. Dwarakanath, PhD, Scientist “F” and Joint Director, Head, Division of Biocybernetics, Institute of Nuclear Medicine and Allied Sciences, DRDO, Ministry of Defence, Delhi, India: Metabolic modifications of radiation response: Implications for therapy and protection. Related information:
- Characterization of protein transacetylase from human placenta as a signaling molecule calreticulin using polyphenolic peracetates as the acetyl group donors. Cell Biochem Biophys. 47:53–64, 2007.
- Ellagic acid peracetates is superior to ellagic acid in the prevention of genotoxicity due to aflatoxin B1 in bone marrow and lung cells. J Pharmacy Pharmacol. 59:1–6:81, 2007.
- Enhancement of radionuclide induced cytotoxicity by 2-deoxy-D-glucose in human tumor cell lines. J Cancer Res Ther. 2:57–64, 2006.
Friday, March 21: Gregory L. King, PhD, Research Physiologist, Radiation Infection Treatment Program, AFRRI: Citrulline—A potential surrogate marker for GI radiation damage. Related information:
- Sublethal gamma-radiation decreases resistance of mice to oral Shigella sonnei challenge. Microbial Ecol Health Dis. 14: 179–190, 2002.
- Nuclear, biological, and chemical combined injuries and countermeasures on the battlefield. Mil Med. 167:95–97, 2002.
- Performance decrement after combined exposure to ionizing radiation and Shigella sonnei. Mil Med. 166:71–73, 2001.
Friday, March 14: John F. Kalinich, PhD, Program Advisor, Internal Contamination and Metal Toxicity Program, AFRRI: Health effects of embedded fragments: Role of AFRRI research on DoD policy. Related information:
- Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats. Environ Health Perspect. 113:729–34, 2005.
- Depleted uranium-uranyl chloride induces apoptosis in mouse J774 macrophages. Toxicology 179:105–14, 2002.
- Health effects of embedded depleted uranium. Mil Med. 167:117–119, 2002.
Friday, March 7: Michael R. Landauer, PhD, Research Toxicologist, Radiation Countermeasures Program, AFRRI: Radioprotection by oral administration of genistein: Related information:
- Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol. 83:141–151, 2007.
- Antibacterial activity of the soy isoflavone genistein. J Basic Microbiol. 46:329–35, 2006.
- Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol. 23:379–385, 2003.
Friday, February 29: Bruce J. Baum, PhD, Chief, Gene Transfer Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Md.: Salivary gland gene therapy—For radiation damage and more. Related information:
- Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates. Hum Gene Ther. 18:142–150, 2007.
- Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther. 15:2101–2106, 2007.
- Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer. J Gene Med. 9:779–787, 2007.
Friday, February 22: Dr. K.S. Kumar, PhD, Research Chemist, Radiation Countermeasures Program, AFRRI: Radioprotection by gamma-tocotrienol. Related information:
- Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. Life Sci. 78:2099–2104, 2006.
- Induction of cytokines by radioprotective tocopherol analogs. Exp Mol Pathol. 81:55–61, 2006.
- High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines. J Radiat Res (Tokyo) 43:361–370, 2002.
Friday, February 15: Dr. William F Blakely, PhD, Program Advisor, Biological Dosimetry, AFRRI: Multiple parameter and integrated radiation biological dosimetry. Related information:
- BiodosEPR-2006 Meeting: Acute dosimetry consensus committee recommendations on biodosimetry applications in events involving uses of radiation by terrorist and radiation accidents. Radiation Measurements 42:972–996, 2007.
- Genistein-induced alterations of radiation-responsive gene expression. Radiation Measurements 42:1152–1157, 2007.
- The use of discriminant analysis for evaluation of early-response multiple biomarkers of radiation exposure using non-human primate 6-Gy whole-body radiation model. Radiation Measurements 42:1158–1163, 2007.
Friday, January 25: Merriline M. Satyamitra, PhD, Research Scientist, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): Persistent neuronal DNA damage following brain irradiation detected by gamma-H2AX expression in histological sections. Related information:
- Inhibition of Akt by the alkylphospholipid perifosine does not enhance the radiosensitivity of human glioma cells. Mol Cancer Ther. 5:1504–-1510, 2006.
- Tracing radiation induced genomic instability in vivo in the haemopoietic cells from fetus to adult mouse. Br J Radiol. 78:928–933, 2005.
- Protection against prenatal irradiation-induced genomic instability and its consequences in adult mice by Ocimum flavonoids, orientin and vicenin. Int J Radiat Biol. 80:653–662, 2004.
Friday, January 18: James B. Mitchell, PhD, Branch Chief, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.: Development of radiation and oxidative stress modifiers. Related information:
- Therapeutic and clinical applications of nitroxide compounds. Antioxid Redox Signal 9:1731–1743, 2007.
- Effects of gamma-radiation on FcepsilonRI and toll-like receptor mediated mast cell activation. J Immunol. 179:3276–3286, 2007.
- Radiation-induced changes in gene-expression profiles for the SCC VII tumor cells grown in vitro and in vivo. Antioxid Redox Signal 8:1263–1272, 2006.
Friday, January 11: Matthias Port, PhD, Intern and Research Fellow, Hannover Medical School, Hannover Clinic for Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover, Germany: Significance of known and detection of new gene expression markers for biological dosimetry on irradiated human peripheral blood. Note: To be held in the AFRRI Board Room. Related information:
- Correcting false gene expression measurements from degraded RNA using RTQ-PCR. Diagn Mol Pathol. 16:38–49, 2007.
- Gene expression profiling in seminoma and nonseminoma. J Clin Oncol. 23:58–69, 2005.
- Influence of high-frequency electromagnetic fields on different modes of cell death and gene expression. Int J Radiat Biol. 79:701–708, 2003.

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