2007 AFRRI Seminars

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Venue

Time: 11 a.m. to 12 noon (unless otherwise noted) each Friday
Place: AFRRI Conference Room, unless otherwise indicated.

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Seminars are presented by AFRRI researchers and other members of the scientific community. While some seminars are open to the public, others are limited to specific audiences. Any exceptions to time, place, and admittance are noted with each item. We do not record or distribute information presented in our Seminar Program. However, where available, references to related information are provided with the seminar title.

2007 seminar schedule

Friday, December 21: Pataje G.S. Prasanna, PhD, Research Biologist, AFRRI: Cytogenetic laboratory automation and inter-laboratory comparison study of the dicentric assay for radiation dose assessment. Related information:
- Sample tracking in an automated cytogenetic biodosimetry laboratory for radiation mass casualties. Radiation Measurements 42:1119–1124, 2007.
- Early-response biological dosimetry—recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Phys. 89:494–504, 2005.
- Radiation biodosimetry: applications for spaceflight. Adv Space Res. 31:1487–1493, 2003.
Friday, December 14: Venkataraman Srinivasan, PhD, Research Biologist, Radiation Countermeasures Program, AFRRI: Evaluation of radiation countermeasure agents: DTRA project (restricted to AFRRI audience). Related information:
- Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxident gamma-tocotrienol. Life Sciences 78:2099–2104, 2006.
- Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol. 23:379–385, 2003.
- Determination of WR-1065 and WR-33278 by liquid chromatography with electrochemical detection. J AOAC Int. 85:551–554, 2002.
Friday, December 7: Marcy B. Grace, PhD, Research Molecular Biologist, Biological Dosimetry Program, AFRRI: In vivo responses to radiation and radiation modifiers. Related information:
- Amylase and blood cell-count hematological radiation-injury biomarkers in a rhesus monkey radiation model—use of multiparameter and integrated biological dosimetry. Radiation Measurements 42:1164–1170, 2007.
- Transcription of five p53- and Stat-3-inducible genes after ionizing radiation. Radiation Measurements 42:1147–1151, 2007.
- Use of a centrifuge-based automated blood cell counter for radiation dose assessment. Mil Med. 171:908–912, 2006.
Wednesday, December 5: Michael C. Joiner, PhD, Professor, Radiation Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Mich. Low-dose hyper-radiosensitivity: How it works and its ramifications. Related information:
- Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activity. Int J Radiat Oncol Biol Phys. 69:1262–1271, 2007.
- MIRD continuing education: Bystander and low dose-rate effects: are these relevant to radionuclide therapy? J Nucl Med. 48:1683–1691, 2007.
- Role of apoptosis in low-dose hyper-radiosensitivity. Radiat Res. 167:260–267, 2007.
Friday, November 16: Michael Daly, PhD, Professor, Department of Pathology, School of Medicine, USUHS: An unconventional model of extreme radiation resistance has practical implications. Related information:
- Deinococcus geothermalis: The pool of extreme radiation resistance genes shrinks. PLoS One 2:e955, 2007.
- Protein oxidation implicated as the primary determinant of bacterial radioresistance. PLoS Biology 5:e92, 2007.
- Accumulation of Mn(II) in Deinococcus radiodurans facilitates gamma-radiation resistance. Science 306:1025–1028, 2004.
Friday, November 9: Douglas Scott Merrell, PhD, Assistant Professor, Department of Microbiology and Immunology, School of Medicine, USUHS: Now infecting more than 3 billion people: Helicobacter pylori, the most successful pathogen in the world. Related information:
- Iron and pH homeostasis intersect at the level of fur regulation in the gastric pathogen Helicobacter pylori. Infect. Immun. 74:602–614, 2006.
- Profiling of microdissected gastric epithelial cells reveals a cell type specific response to Helicobacter pylori infection. Gastroenterology 127:1446–1462, 2004.
- Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers. J Infect Dis. 190:1516–1523, 2004.
Friday, November 2: Martin Hauer-Jensen, MD, PhD, FACS, Professor of Surgery and Pathology, University of Arkansas for Medical Sciences Arkansas Cancer Research Center, Little Rock, Ark.: Endothelial-oriented protection strategies against combined radiation and traumatic injuries. Related information:
- Local administration of interleukin-11 ameliorates intestinal radiation injury in rats. Cancer Res. 67:9501–9516, 2007.
- Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy. World J Gastroenterol. 13:3047–3055, 2007.
- Orazipone, a locally acting immunomodulator, ameliorates intestinal radiation injury: a preclinical study in a novel rat model. Int J Radiat Oncol Biol Phys. 66:552–559, 2006.
Friday, October 26: Alexandra C. Miller, PhD, Principal Investigator, Radiation Countermeasure Program, AFRRI: Prevention of radiation-induced late effects by phenylacetate and phenylbutyrate. Related information:
- A review of depleted uranium biological effects: in vitro and in vivo studies. Rev Environ Health 22:75–89, 2007.
- Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium. Mol Cell Biol. 279:97–104, 2005.
- Suppression of depleted uranium-induced neoplastic transformation of human cells by the phenyl acid, phenyl acetate: chemoprevention by targeting the p21RAS protein pathway. Radiat Res. 155:163–170, 2001.
Friday, October 19: Robert J. Lowy, PhD, Principal Investigator, AFRRI: Differences in NF-κB and AP-1 response by macrophages exposed to ionizing radiation, LPS, and influenza A virus.
Friday, October 12: Natalia I. Ossetrova, PhD, Research Associate (National Research Council–The National Academies), Biological Dosimetry Program, AFRRI: In vivo murine dose-response calibration curves for early-response exposure assessment using multiple radiation-responsive blood protein biomarkers. Related information:
- High-sensitivity blood-based detection of breast cancer by diagnostic proteomics. J. Proteome Res. 5:1906–1915, 2006.
- Ultra-high sensitivity multi-photon detection imaging in proteomics analyses. Proteomics 5:2322–2330 2005.
- Ultra-sensitive immunoassays using multi-photon-detection in diagnostic proteomics of blood. J Proteome Res. 4:2375–2387, 2005.
Friday, October 5: Mark H. Whitnall, PhD, Program Advisor, Radiation Countermeasures, AFRRI: 5-Androstenediol modulation of radiation-induced death and differentiation in hematopoietic progenitor cells: Signaling mechanisms in mice and humans. Related information:
- 5-Androstenediol promotes survival of gamma-irradiated human hematopoietic progenitors through induction of nuclear factor-kappaB activation and granulocyte colony-stimulating factor expression. Mol Pharmacol. 72:370–379, 2007.
- Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF. Immunopharmacol Immunotoxicol. 27:521–534, 2005.
- Radioprotective efficacy and acute toxicity of 5-androstenediol after subcutaneous or oral administration in mice. Immunopharmacol Immunotoxicol. 24:595–626, 2002.
Friday, September 28: Mansoor M. Ahmed, PhD, Staff Scientist, Weis Center for Research, Geisinger Clinic, Danville, Penna.: Modulation of TGF-beta signaling and radiation response in solid tumors and normal tissues. Related information:
- Inhibition of transforming growth factor-beta signaling in normal lung epithelial cells confers resistance to ionizing radiation. Int J Rad Oncol Biol Phys. 68:187–195, 2007.
- Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosis. Cancer Biol Ther. 4:979–986, 2005.
- Modulation of gene expression in human central nervous system tumors under methionine deprivation induced stress. Cancer Res. 64:7513–7525, 2004.
Friday, September 14: Viatcheslav A. Solatenkov, MD, PhD, Associate Professor, Departments of Radiation Medicine and Microbiology & Immunology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC: The role of poly(ADP-ribose) polymerase in radiation-induced transcription. Related information:
- Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma. Clin Cancer Res. 12:6781–6790, 2005.
- Specific binding of poly(ADP-ribose) polymerase-1 to cruciform hairpins. J Mol Biol. 348:609–615, 2005.
- Regulation of poly(ADP-ribose) polymerase-1 by DNA structure-specific binding. J Biol Chem. 280:17076–17083, 2005.
Friday, September 7: Vitaly Nagy, PhD, Dosimetry Division, Radiation Science Department, AFRRI: Radiation dosimetry at AFRRI.
Friday, July 27: Thomas J. MacVittie, PhD, Professor, University of Maryland School of Medicine, Deptments of Radiation Oncology and Pathology, Baltimore, Md.: Managing the ARS after a nuclear terrorist event: Timing in life is everything. Related information:
- Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF. Health Phys. 89:546–55, 2005.
- Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Radiat Res. 162:711–28, 2004.
- Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med. 140:1037–51, 2004.
Friday, July 20: Karen Marie Wolcott, Director, Flow Cytometry Facility, Biomedical Instrumentation Center, Uniformed Services University of the Health Sciences: I didn't know you can use flow cytometry for that.
Friday, June 29: Maria Moroni, PhD, Research Associate, Henry M. Jackson Foundation (Biological Dosimetry Program, AFRRI): Differential response of normal and tumor cells to radioprotectants. Related information:
- Progressive loss of Syk and abnormal proliferation in breast cancer cells. Cancer Res. 64, 7346–7354, 2004.
- Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway. Oncogene 22:7998–8011, 2003.
- Oxidative modification of aldose reductase induced by copper ion. Definition of the metal-protein interaction mechanism. J Biol Chem. 277, 42017–42027, 2002.
Friday, June 22: Steven R. Mog, Chief, Division of Comparative Pathology, Veterinary Sciences Department, AFRRI: The AFRRI IACUC review process. Related information:
- Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. Int J Radiat Biol. 83:141–151, 2007
- Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats. Environ Health Perspect. 113:729–734, 2005.
- Pathogenicity and immune response measured in mice following intranasal challenge with enterotoxigenic Escherichia coli strains H10407 and B7A. Infect Immun. 71:13–21, 2003.
Friday, June 15: Mang Xiao, MD, Scientist, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): Hematological niche and radiation. Related information:
- Jun blockade of erythropoiesis: Role for repression of GATA-1 by HERP2. Mol Cell Biol. 24:7779–7794, 2004.
- Analysis of primitive CD34- and CD34+ hematopoietic cells from adults: gain and loss of CD34 antigen by undifferentiated cells are closely linked to proliferative status in culture. Stem Cells 22:556–569, 2004.
- Assessment of cell viability and apoptosis in human umbilical cord blood (UCB) following storage. J Hematother Stem Cell Res. 12:115–122, 2003.
Friday, June 8: Juliann G. Kiang, PhD, Research Biologist, Combined Injury Program, AFRRI: Protective effects of 5-AED on combined injury: Down-regulation of iNOS pathway. Related information:
- Raman scattering studies of the low frequency vibrational modes of bacteriophage M13 in water—observation of an axial torsion mode. Nanotechnology 17:5474–5479, 2006.
- Androstenediol inhibits trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway. J App Physiol. 102:933–941, 2007.
- Subpicosecond time-resolved Raman studies of field-induced transient transport in an In_xGa1_−xAs-based p-i-n semiconductor nanostructure. App Physics Lett. 89:262101-1, 2006.
Friday, June 1: Andre Dubois, MD, PhD, Professor of Medicine, Surgery, and Emerging Infectious Diseases, Chief, Laboratory of Gastrointestinal and Liver Studies USUHS: Helicobacter pylori infection. Related information:
- Molecular characterization of Helicobacter pylori strains isolated from cynomolgus monkeys (M. fascicularis). Vet Microbiol. 108:133–139, 2005.
- Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric precancerous intestinal metaplasia and adenocarcinoma. J Infect Dis. 187:1165–1177, 2003.
- Treatment of Helicobacter pylori infection in rhesus monkeys using a novel antiadhesion compound. Gastroenterology 117:1316–1325, 1999.
Friday, May 25: Harvey B. Pollard, MD, PhD, Professor and Chair, Departments of Anatomy, Physiology and Genetics, School of Medicine, USUHS: Protein microarrays for systems biology, clinical proteomics, and drug discovery. Related information:
- Pharmacoproteomics of 4-phenylbutyrate-treated IB3-1 cystic fibrosis bronchial epithelial cells. J Proteome Res. 5:562–571, 2006.
- De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cells. Mol Cell Proteomics 5:1628–1637, 2006.
- Distinct effects of Annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription. Cancer Res. 66:9609–-9616, 2006.
Friday, May 18: Vijay K Singh, PhD, Department of Radiation Biology, School of Medicine, Radiation Countermeasure Program, AFRRI: Evaluation of a novel truncated flagellin radiation countermeasure. Related information:
- Induction of cytokines by radioprotective tocopherol analogs. Expt Mol Pathol. 81:55–61, 2006.
- Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSF. Immunopharmacol Immunotoxicol. 27:521–534, 2005.
- Radioprotection by N-palmitoylated nonapeptide of human interleukin-1beta. Peptides 26:413–418, 2005.
Friday, May 11: Meera Srivastava, PhD, Professor, Department of Anatomy, Physiology and Genetics, School of Medicine, USUHS: ANXA7 signaling mechanisms in cancer. Related information:
- Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription. Cancer Res. 66:9609–16, 2006.
- De novo biosynthetic profiling of high abundance proteins in cystic fibrosis lung epithelial cells. Mol Cell Proteomics 5:1628–37, 2006.
- Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Proc Natl Acad Sci USA 102, 9631–9636, 2005.
Friday, May 4: Joseph G. Harre, DVM, Lieutenant Colonel, U.S. Army Veterinary Corps, Head, Veterinary Sciences Department, AFRRI: Writing an AFRRI IACUC protocol. Related information:
- Functional assessment of a new staple line reinforcement in lung resection. Surg Res. 131:49–52, 2006.
- Increased burst pressure in gastrointestinal staple-lines using reinforcement with a bioprosthetic material. Obes Surg. 15:1379–83, 2005.
- Rofecoxib does not adversely affect skin graft survival in a rat model. Curr Surg. 61:227–230, 2004.
Friday, April 27: Irshad Chaudry, PhD, Professor, Departments of Surgery, Microbiology, Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Ala.: Sex steroids and receptor antagonists: The good, the bad, and the ugly adjuncts for improving cardiovascular and immunological functions following trauma-hemorrhage. Related information:
- A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. Ann Surg. 244:131–138, 2006.
- Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis. Cytokine 34:76–84, 2006.
- Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis. Am J Physiol Gastrointest Liver Physiol. 291:G260–266, 2006.
Friday, April 20: Sanchita Ghosh, PhD, Research Investigator, Henry M. Jackson Foundation (Radiation Countermeasures Program, AFRRI): Radioprotectant Ex-Rad: Efficacy and mechanism. Related information:
- The role of cysteines and charged amino ccid in extracellular loops of the human Ca²⁺ receptor in cell surface expression and receptor activation processes. Endocrinology 145:3892–3903, 2004.
Friday, April 13: William Samuel, PhD, Staff Scientist, Laboratory of Retinal Cell and Molecular Biology, NEI, NIH, Bethesda, Md.: Reactive oxygen species mediated apoptosis. Related information:
- N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153. J Cell Physiol. 209:854–865, 2006.
- Transforming growth factor-beta regulates stearoyl coenzyme A desaturase expression through a Smad signaling pathway. J Biol Chem. 277:59-66, 2002.
- Regulation of stearoyl coenzyme A desaturase expression in human retinal pigment epithelial cells by retinoic acid. J Biol Chem. 276:28744–28750, 2001.
Friday, April 6: Theodor A. Zainal, PhD, Biochemist, Radiation Countermeasure Program, AFRRI: Evaluation of histidine-containing dipeptides as radiation countermeasure agents (restricted to AFRRI audience). Related information:
- Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J. 14:1825–1836, 2000.
- Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med. 26:1181–1193, 1999.
- Localization and expression of cornifin-alpha/SPRR1 in mouse epidermis, anagen hair follicles, and skin neoplasms. J Invest Dermatol. 106:647–54, 1996.
Friday, March 30: G. David Ledney, PhD, Research Biologist, Radiation Infection Treatment group, AFRRI: Countermeasures to combined injury in radiation threat environments. Related information:
- Antibacterial activity of the soy isoflavone genistein. J Basic Microbiol. 46:329–335, 2006.
- Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without ⁶⁰Co gamma-photon irradiation. J Med Microbiol. 54:1157–1162, 2005.
- Clindamycin and quinolone therapy for Bacillus anthracis Sterne infection in ⁶⁰Co-gamma-photon-irradiated and sham-irradiated mice. J Antimicrob Chemother. 56:1074–1080, 2005.
Wednesday, March 28: Loke Weng Keong, PhD, Defense Scientist, Chemical, Biological and Radiological Defense Program, Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore: Overview of chemical agent medical countermeasures research in DSO national laboratories.
Friday, March 23: John F. Kalinich, PhD, Research Biochemist, Embedded Heavy Metals Program, AFRRI: Health effects of embedded tungsten alloy and depleted uranium. Related information:
- Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats. Environ Health Perspect. 113:729–734, 2005.
- Depleted uranium-uranyl chloride induces apoptosis in mouse J774 macrophages. Toxicology 179:105–114, 2002.
- Health effects of embedded depleted uranium. Mil Med. 167(2 Suppl):117–119, 2002.
Friday, March 16: Gregory L. King, PhD, Research Physiologist, Radiation Infection Treatment Program, AFRRI: A review of surrogate markers for GI radiation damage. Related information:
- Nuclear, biological, and chemical combined injuries and countermeasures on the battlefield. Mil Med. 167:95–7, 2002.
- 5-HT3 receptor antagonists ameliorate emesis in the ferret evoked by neutron or proton radiation. Aviat Space Environ Med. 70:485–92, 1999.
Friday, March 9: Venkataraman Srinivasan, PhD, Research Biologist, Radiation Countermeasure Program, AFRRI: Radiation countermeasure screening: AFRRI-NIAID project (restricted to AFRRI audience). Related information:
- Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol., 23:379–385, 2003.
- Determination of WR-1065 and WR-33278 by liquid chromatography with electrochemical detection. J AOAC Int. 85:551–554, 2002.
- Radioprotection, pharmacokinetic and behavioural studies in mouse implanted with biodegradable drug (amifostine) pellets. Int J Radiat Biol. 78:535–543, 2002.
Friday, March 2: Cheng-min Chang, PhD, Research Biologist, Radiation Countermeasure Program, AFRRI: Effect of 5-AED on RNA content in irradiated mice. Related information:
- New strategies for the prevention of radiation injury: possible implications for countering radiation hazards of long-term space travel. J Radiat Res (Tokyo) 43 Suppl:S239–44, 2002.
- Ionizing radiation and bacterial challenge alter splenic cytokine gene expression. J Radiat Res (Tokyo) 41:259–77, 2000.
- Sublethal gamma irradiation increases IL-1alpha, IL-6, and TNF-alpha mRNA levels in murine hematopoietic tissues. J Interferon Cytokine Res. 17:567–72, 1997.
Friday, February 23: Thomas B. Elliott, PhD, Research Microbiologist, Radiation Infection Treatment Program, AFRRI: Pharmacokinetics and antimicrobial therapy of post-irradiation sepsis. Related information:
- Antimicrobial therapy for bacillus anthracis-induced polymicrobial infection in ⁶⁰Co gamma-irradiated mice. Antimicrob Agents Chemother. 46:3463–3471, 2002.
- Bacillus anthracis infection in irradiated mice: susceptibility, protection, and therapy. Mil Med. 167:103–104, 2002.
Friday, February 16: William F. Blakely, PhD, Senior Scientist and Scientific Advisory Board Member, Biological Dosimetry Program, AFRRI: Multiparameter and integrated biological dosimetry. Related information:
- Early-response biological dosimetry--recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Phys. 89:494–504, 2005.
- Radiation biodosimetry: applications for spaceflight. Adv Space Res. 31:1487–1493, 2003.
- Radiation exposure assessment using cytological and molecular biomarkers. Radiat Prot Dosimetry, 97:17–23, 2001.
Friday, February 2: Michael R. Landauer, PhD, Principal Investigator, Radiation Countermeasures Program, AFRRI: Radiation protection by genistein and daidzein: Recent developments. Related information:
- Antibacterial activity of the soy isoflavone genistein. J Basic Microbiol. 46:329–335, 2006.
- Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol. 23:379–385, 2003.
- Radioprotection, pharmacokinetic and behavioural studies in mouse implanted with biodegradable drug (amifostine) pellets. Int J Radiat Biol. 78:535–543, 2002.
Friday, January 26: Tzu-Cheg Kao, PhD, Professor, Division of Epidemiology and Biostatistics, Department of Preventive Medicine and Biometrics, USUHS Senior Statistician, Office of Biostatistics, AFRRI: Statistical consultation and collaborative research with scientists at AFRRI.
Friday, January 19: John R. Mercier, PhD, COL, USA, Director, Military Training and Doctrine, AFRRI: Health physics issues in OIF. Related information:
- Dose response relationships for acute ionizing radiation lethality. Health Physics 84: 565–575, 2003.
- Comparison of five methods for the derivation of spectra for a constant potential dental X-ray unit. Dentomaxillofacial Radiology 30:264–269, 2001.
- Measurement and validation of benchmark-quality thick-target tungsten X-ray spectra below 150 kVp. Radiat Res. 154:564–581, 2000.
Friday, January 12: Alexandra C. Miller, PhD, Principal Investigator Radiation Countermeasure Program, AFRRI: Development of models to study radiation-induced late effects. Related information:
- Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium. Mol Cell Biol. 279:97–104, 2005.
- Radiation- and depleted uranium-induced carcinogenesis studies: Characterization of the carcinogenic process and development of medical countermeasures. Proceedings of the Human Factors and Medicine (HFM) Panel Research Task Group (RTG) 099 Meeting, "Radiation Bioeffects and Countermeasures," Bethesda, MD, USA, June 21–23, 2005. Compact disc: AFRRI CD 05-2, 2005.
- Suppression of depleted uranium-induced neoplastic transformation of human cells by the phenyl fatty acid, phenyl acetate: chemoprevention by targeting the p21RAS protein pathway. Radiat Res. 155:163–70, 2001.
Friday, January 5: K.S. Kumar, PhD, Research Chemist, Radiation Counterneasures Program, AFRRI: Radioprotection by nutraceutical tocols. Related information:
- Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. Life Sci. 78:2099–104, 2006.
- High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines. J Radiat Res (Tokyo) 43:361–370, 2002.
- Radioprotection, pharmacokinetic and behavioural studies in mouse implanted with biodegradable drug (amifostine) pellets. Int J Radiat Biol. 78:535–243, 2002.

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